3-氨基-4-(环己基氨基)苯甲酸甲酯合成路线 （共 7 条）
反应条件
palladium in methanol; ethyl acetate
参考文献
Priestley, Eldon Scott; Decicco, Carl P.; Hudyma, Thomas W.; Zheng, Xiaofan
Patent: US2003/134853 A1, 2003 ;
反应条件
palladium on activated charcoal; hydrogen in acetic acid
T=20°C; P=6000.6 Torr;
参考文献
Brink, Mikael; Dahlen, Anders; Olsson, Thomas; Polla, Magnus; Svensson, Tor
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2261 - 2268
反应条件
1: sulfuric acid / 0.25 h / 80 °C / |Microwave irradiation; |Inert atmosphere
2: dichloromethane / 0.17 h / 80 °C / |Microwave irradiation; |Inert atmosphere
3: zinc; ammonium formate / methanol / 0.08 h / 90 °C / |Microwave irradiation; |Inert atmosphere
View Scheme
参考文献
Maiti, Barnali; Chanda, Kaushik; Selvaraju, Manikandan; Tseng, Chih-Chung; Sun, Chung-Ming
ACS Combinatorial Science, 2013 , vol. 15, # 6 p. 291 - 297
反应条件
1: dichloromethane / 0.17 h / 80 °C / |Microwave irradiation; |Inert atmosphere
2: zinc; ammonium formate / methanol / 0.08 h / 90 °C / |Microwave irradiation; |Inert atmosphere
View Scheme
参考文献
Maiti, Barnali; Chanda, Kaushik; Selvaraju, Manikandan; Tseng, Chih-Chung; Sun, Chung-Ming
ACS Combinatorial Science, 2013 , vol. 15, # 6 p. 291 - 297
反应条件
1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 17 h / 0 - 20 °C / |Inert atmosphere
2: potassium carbonate / dimethyl sulfoxide / 17 h / 60 °C
3: palladium(II) oxide hydrate; hydrogen / methanol / 17 h / 20 °C
View Scheme
参考文献
Skouta, Rachid; Dixon, Scott J.; Wang, Jianlin; Dunn, Denise E.; Orman, Marina; Shimada, Kenichi; Rosenberg, Paul A.; Lo, Donald C.; Weinberg, Joel M.; Linkermann, Andreas; Stockwell, Brent R.
Journal of the American Chemical Society, 2014 , vol. 136, # 12 p. 4551 - 4556
反应条件
1: methanol / 20 °C / |Reflux
2: palladium on activated charcoal; hydrogen / acetic acid / 20 °C / 6000.6 Torr
View Scheme
参考文献
Brink, Mikael; Dahlen, Anders; Olsson, Thomas; Polla, Magnus; Svensson, Tor
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2261 - 2268
反应条件
1: potassium carbonate / dimethyl sulfoxide / 17 h / 60 °C
2: palladium(II) oxide hydrate; hydrogen / methanol / 17 h / 20 °C
View Scheme
参考文献
Skouta, Rachid; Dixon, Scott J.; Wang, Jianlin; Dunn, Denise E.; Orman, Marina; Shimada, Kenichi; Rosenberg, Paul A.; Lo, Donald C.; Weinberg, Joel M.; Linkermann, Andreas; Stockwell, Brent R.
Journal of the American Chemical Society, 2014 , vol. 136, # 12 p. 4551 - 4556
