6-氟-3,4-二氢-1H-异苯并吡喃合成路线 （共 3 条）
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile
T=20°C; 5 h;
参考文献
Reisman, Sarah E.; Doyle, Abigail G.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2008 , vol. 130, # 23 p. 7198 - 7199
反应条件
1: 47 percent / HCl / -10 - -5 °C
2: 77 percent / conc. H2SO4 / 5 h / 80 - 90 °C
View Scheme
参考文献
Unterhalt; Joestingmeier
Pharmazie, 1996 , vol. 51, # 9 p. 641 - 644
反应条件
1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / Inert atmosphere; Reflux
2: toluene-4-sulfonic acid; lithium bromide / 24 h / Inert atmosphere; Reflux
3: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Maity, Prantik; Srinivas, Harathi D.; Watson, Mary P.
Journal of the American Chemical Society, 2011 , vol. 133, # 43 p. 17142 - 17145
