1: 2-aminopyridine With sodium hydride in tetrahydrofuran
T=55°C;
2: 2-bromo-1,3-thiazole in tetrahydrofuran
T=0 - 55°C;
参考文献
Misra, Raj N.; Xiao, Hai-Yun; Williams, David K.; Kim, Kyoung S.; Lu, Songfeng; Keller, Kristen A.; Mulheron, Janet G.; Batorsky, Roberta; Tokarski, John S.; Sack, John S.; Kimball, S. David; Lee, Francis Y.; Webster, Kevin R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 11 p. 2973 - 2977
1: acetone / 1 h / Heating
2: NaOHaq / H2O / 0.08 h / Heating
3: 1.4 g / H2O / 2 h / Heating
View Scheme
参考文献
Das, Jagabandhu; Furch, Joseph A.; Liu, Chunjian; Moquin, Robert V.; Lin, James; Spergel, Steven H.; McIntyre, Kim W.; Shuster, David J.; O'Day, Kathleen D.; Penhallow, Becky; Hung, Chen-Yi; Doweyko, Arthur M.; Kamath, Amrita; Zhang, Hongjian; Marathe, Punit; Kanner, Steven B.; Lin, Tai-An; Dodd, John H.; Barrish, Joel C.; Wityak, John
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3706 - 3712
Cunningham, Ian D.; Blanden, James S.; Llor, Juan; Munoz, Luis; Sharratt, Andrew P.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , p. 1747 - 1750
