反应条件
1: 5-[(2-Chloro-4-pyrimidinyl)acetyl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide With N-bromosuccinmide in dichloromethane 0.333333 h; 2: 2-aminopyridine in 1,4-dioxane; dichloromethane T=20 - 60°C; 64 h; 3: With sodium hydrogencarbonate in 1,4-dioxane; dichloromethane; water
参考文献
Kuntz, Kevin; Uehling, David Edward; Waterson, Alex Gregory; Emmitte, Kyle Allen; Stevens, Kirk; Shotwell, John Brad; Smith, Stephon Cornell; Nailor, Kristen E.; Salovich, James M.; Wilson, Brian John; Cheung, Mui; Mook, Robert Anthony; Baum, Erich W.; Moorthy, Ganesh
Patent: US2008/300242 A1, 2008 ;
Location in patent: Page/Page column 37-38 ;
US 20080300242 A1