反应条件
1.1: sulfuric acid; sulfur trioxide / 4 h / 140 °C 2.1: bromine / water / 1 h / Reflux 3.1: hydrogenchloride; sodium nitrite / water / 1.5 h / 0 - 25 °C / Cooling with ice 3.2: 3 h / 125 °C 4.1: triethylamine / dichloromethane / 1 h / 0 °C / Cooling with ice 5.1: ethanol / 18 h / Reflux 6.1: tetrakis(triphenylphosphine) palladium(0) / 18 h / 100 °C / 10343.2 Torr 7.1: sodium hydroxide / ethanol / 2 h / 20 - 25 °C 7.2: pH 5 8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h View Scheme
参考文献
Rawson, David J.; Ballard, Stephen; Barber, Christopher; Barker, Laura; Beaumont, Kevin; Bunnage, Mark; Cole, Susan; Corless, Martin; Denton, Stephen; Ellis, David; Floc'H, Marion; Foster, Laura; Gosset, James; Holmwood, Frances; Lane, Charlotte; Leahy, David; Mathias, John; Maw, Graham; Million, William; Poinsard, Cedric; Price, Jenny; Russel, Rachel; Street, Stephen; Watson, Lesa
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 498 - 509