1-氨基-3-苯基丙烷-2-醇合成路线 （共 12 条）
反应条件
in tetrahydrofuran T=20°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/121786 A1, 2008 ;
Location in patent: Page/Page column 40 ;
WO 2008/121786 A1
反应条件
ammonia in water
T=110°C; 0.5 h; Microwave;
参考文献
UNIVERSITY OF WOLLONGONG
Patent: WO2006/74501 A1, 2006 ;
Location in patent: Page/Page column 75 ;
反应条件
hydrogen; palladium on activated charcoal in methanol
T=50°C; 19 h;
参考文献
Yamashita, Mitsuo; Ojima, Iwao
Journal of the American Chemical Society, 1983 , vol. 105, # 20 p. 6339 - 6342
反应条件
1: tetrahydrofuran / Heating
2: H2O / Heating
View Scheme
参考文献
Carite; Alazard; Ogino; Thal
Tetrahedron Letters, 1990 , vol. 31, # 48 p. 7011 - 7014
反应条件
hydrogen; palladium on activated charcoal in methanol
T=50°C; 19 h;
参考文献
Ojima, Iwao; Shimizu, Nobuko; Qiu, Xiaogang; Chen, Hauh-Jyun C.; Nakahashi, Kazuaki
Bulletin de la Societe Chimique de France, 1987 , # 5 p. 649 - 658
反应条件
1: 96 percent / AlH2Cl / diethyl ether / 1.5 h / 34 °C
2: 94 percent / H2 / Pd-C / methanol / 19 h / 50 °C
View Scheme
参考文献
Yamashita, Mitsuo; Ojima, Iwao
Journal of the American Chemical Society, 1983 , vol. 105, # 20 p. 6339 - 6342
反应条件
lithium aluminium tetrahydride in diethyl ether
3 h; Heating;
参考文献
Filitis, L. N.; Akalaeva, T. V.; Amel'kin, O. Yu.; Bokanov, A. I.; Ivanov, P. Yu.; Shvedov, V. I.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 10 p. 780 - 785
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 10 p. 1217 - 1222
反应条件
1: 96 percent / monochlorohydroalane / diethyl ether / 1.5 h / 34 °C
2: 94 percent / H2 / 10percent Pd-C / methanol / 19 h / 50 °C
View Scheme
参考文献
Ojima, Iwao; Zhao, Mangzhu; Yamato, Takehiko; Nakahashi, Kazuaki; Yamashita, Mitsuo; Abe, Rumiko
Journal of Organic Chemistry, 1991 , vol. 56, # 18 p. 5263 - 5277
反应条件
1: MCPBA / CH2Cl2
2: NaN3 / H2O; acetonitrile
3: tetrahydrofuran / Heating
4: H2O / Heating
View Scheme
参考文献
Carite; Alazard; Ogino; Thal
Tetrahedron Letters, 1990 , vol. 31, # 48 p. 7011 - 7014
反应条件
1: ZnI2
2: LiAlH4 / diethyl ether
View Scheme
参考文献
Moree, Wilna J.; Marel, Gijs A. van der; Liskamp, Rob J.
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5157 - 5169
