2-溴-1-(4-甲磺酰基)苯乙酮合成路线 （共 24 条）
反应条件
bromine; acetic acid T=20°C;
参考文献
EP912537 B1, ;
Page 8-9 ;
反应条件
3-chloro-benzenecarboperoxoic acid T=-5 - 0°C; 3 h;
参考文献
EP1246825 B1, ;
Page 25 ;
反应条件
1: 100 percent / MMPP / methanol; CH2Cl2 / 3 h / 20 °C 2: 86 percent / Br2; AlCl3 / CHCl3 / -5 °C View Scheme
参考文献
Synthesis, , # 12 p. 1778 - 1779
反应条件
bromine; sodium hydrogencarbonate; MMPP; AlCl3 in methanol; hexane; chloroform; water; ethyl acetate
反应条件
bromine; AlCl3 in hexane; chloroform; ethyl acetate
反应条件
hydrogenchloride; bromine in (4-methanesulphonylphenyl)-ethanone; acetic acid
反应条件
hydrogenchloride; bromine in water; acetic acid
反应条件
1: 98.5 percent / tetrahydrofuran; diethyl ether / 1.) -78 deg C - RT, 2.) RT, 2.5 h 2: 91 percent / mCPBA / CH2Cl2 / Ambient temperature 3: 15.7 g / HCl, bromine / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 253 - 266
反应条件
1: 82 percent / AlCl3 / CHCl3 / 1.5 h / 5 °C 2: 100 percent / MMPP / methanol; CH2Cl2 / 3 h / 20 °C 3: 86 percent / Br2; AlCl3 / CHCl3 / -5 °C View Scheme
参考文献
Synthesis, , # 12 p. 1778 - 1779
反应条件
diisopropylamine in DMF (N,N-dimethyl-formamide) T=40°C; 4.5 h;
参考文献
Liu, Gai-Zhi; Xu, Hai-Wei; Wang, Peng; Lin, Zong-Tao; Duan, Ying-Chao; Zheng, Jia-Xin; Liu, Hong-Min
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 323 - 336
