2-溴-1-(4-甲磺酰基)苯乙酮合成路线 （共 24 条）
反应条件
triethylamine in acetonitrile T=25°C; 0.5 h;
参考文献
Argade, Anil; Desai, Jigar; Thombare, Pravin; Shah, Kiran; Gite, Sanjay; Prajapati, Vijay; Pandey, Bipin; Jain, Mukul; Patel, Pankaj; Bahekar, Rajesh
Synthetic Communications, 2012 , vol. 42, # 21 p. 3140 - 3149
反应条件
potassium carbonate in dichloromethane; water
参考文献
Crespo Crespo, Maria Isabel; Jimenez Mayorga, Juan Miguel; Puig Duran, Carles; Soca Pueyo, Lidia
Patent: US2002/45644 A1, 2002 ;
反应条件
in acetonitrile T=80°C; Microwave irradiation;
参考文献
Steenackers, Hans P. L.; Ermolatev, Denis S.; Savaliya, Bharat; De Weerdt, Ami; De Coster, David; Shah, Anamik; Van Der Eycken, Erik V.; De Vos, Dirk E.; Vanderleyden, Jozef; De Keersmaecker, Sigrid C. J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 2 p. 472 - 484
反应条件
1: phenylacetic acid With sodium hydroxide in DMF (N,N-dimethyl-formamide); water T=4°C; 1 h; 2: 2-bromo-l-(4-(methylsulfonyl)-phenyl)-ethanone With diisopropylamine T=45°C; 3.5 h;
参考文献
MERCK and CO., INC.
Patent: EP912537 B1, 2004 ;
Location in patent: Page 13 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
参考文献
Merck Frosst Canada, Inc.
Patent: US5849943 A1, 1998 ;
反应条件
triethylamine in N,N-dimethyl-formamide T=0 - 30°C; Horner-Wadsworth-Emmons Olefination; 2 h; Inert atmosphere;
参考文献
Argade, Anil; Desai, Jigar; Thombare, Pravin; Shah, Kiran; Gite, Sanjay; Prajapati, Vijay; Pandey, Bipin; Jain, Mukul; Patel, Pankaj; Bahekar, Rajesh
Synthetic Communications, 2012 , vol. 42, # 21 p. 3140 - 3149
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in water; acetonitrile
参考文献
Merck Frosst Canada Inc.
Patent: US5691374 A1, 1997 ;
反应条件
1: Et3N / acetonitrile / 0.5 h / 25 °C 2: DBU / acetonitrile / 0.5 h / 0 °C View Scheme
参考文献
Zarghi, Afshin; Rao, P.N. Praveen; Knaus, Edward E.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 8 p. 1957 - 1960
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=70°C;
参考文献
Merck Frosst Canada, Inc.
Patent: US5767291 A1, 1998 ;
反应条件
hydrogenchloride in ethyl acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetonitrile
参考文献
Merck Frosst Canada, Inc.
Patent: US5849943 A1, 1998 ;
