2-氨基-3,4-二甲基苯甲酸合成路线 （共 15 条）
反应条件
1: With nitric acid T=0°C; 10 h; 2: With hydrogen; palladium on activated charcoal in methanol P=2844.31 Torr; 10 h;
参考文献
Atwell, Graham J; Yang, Shangjin; Denny, William A
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 10 p. 825 - 828
反应条件
potassium hydroxide; potassium chloride; dihydrogen peroxide T=20°C;
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
1: Na2SO4, hydroxylamine sulfate, concd. HCl / H2O 2: 65 percent / CH3SO3H / 70 - 80 °C 3: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C View Scheme
参考文献
Wright, Karen; Alvarez, Antonio Blanco; Crisma, Marco; Toffoletti, Antonio; Formaggio, Fernando; Toniolo, Claudio
Helvetica Chimica Acta, 2012 , vol. 95, # 12 p. 2446 - 2459
反应条件
1: 86percent H2SO4 / 1) 55 deg C, 10 min, 2) 75 deg C, 30 min 2: H2O2, NaOH View Scheme
参考文献
Baker et al.
Journal of Organic Chemistry, 1952 , vol. 17, p. 149,153
反应条件
hydrogen; palladium on activated charcoal
参考文献
Braendstroem,A.; Carlsson,A.I.
Acta Chemica Scandinavica (1947-1973), 1967 , vol. 21, p. 983 - 992
反应条件
1: AlCl3 2: HNO3 3: NaOCl 4: H2 / Pd-C View Scheme
参考文献
Braendstroem,A.; Carlsson,A.I.
Acta Chemica Scandinavica (1947-1973), 1967 , vol. 21, p. 983 - 992
反应条件
1: NaOCl 2: H2 / Pd-C View Scheme
参考文献
Braendstroem,A.; Carlsson,A.I.
Acta Chemica Scandinavica (1947-1973), 1967 , vol. 21, p. 983 - 992
反应条件
1: HNO3 2: NaOCl 3: H2 / Pd-C View Scheme
参考文献
Braendstroem,A.; Carlsson,A.I.
Acta Chemica Scandinavica (1947-1973), 1967 , vol. 21, p. 983 - 992
反应条件
1: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C 2: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C 3: 70 percent / concd. H2SO4 / H2O / 0.17 h / 80 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
sulfuric acid; potassium iodide; sodium nitrite 1.) water, 10 deg C, 2.) 100 deg C; Yield given. Multistep reaction;
参考文献
ANTISOMA RESEARCH LIMITED
Patent: WO2009/53681 A1, 2009 ;
Location in patent: Page/Page column 31 ;
