2-氨基-3,4-二甲基苯甲酸合成路线 （共 15 条）
反应条件
1: With sulfuric acid; sodium nitrite in water T=0 - 2°C; 0.25 h; 2: With potassium iodide in water T=0 - 75°C;
参考文献
Atwell, Graham J; Yang, Shangjin; Denny, William A
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 10 p. 825 - 828
反应条件
1: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C 2: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
(i) aq. HCl, NaNO2, (ii) NH2OH*H2SO4, CuSO4, aq. NH3, aq. NaOH, (iii) Zn, aq. NaOH; Multistep reaction;
参考文献
Fritsch, Rainer; Hartmann, Erwin; Andert, Doris; Mannschreck, Albrecht
Chemische Berichte, 1992 , vol. 125, # 4 p. 849 - 856
反应条件
1: With sulfuric acid; sodium nitrite in water
T=0 - 2°C; 0.25 h;
2: With potassium iodide in water
T=0 - 75°C;
参考文献
Atwell, Graham J; Yang, Shangjin; Denny, William A
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 10 p. 825 - 828
反应条件
urea in water; ethyl acetate
参考文献
Hoffmann-La Roche Inc.
Patent: US5688803 A1, 1997 ;
