2-(4-硝基苯基)乙酰氯合成路线 （共 63 条）
反应条件
1: xylene / Heating 2: KOH / methanol View Scheme
参考文献
Kipping,C. et al.
Journal fuer Praktische Chemie (Leipzig), 1973 , vol. 315, # 5 p. 887 - 894
反应条件
1: NaHCO3 / acetone / 6 h / Ambient temperature 2: H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature 3: LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Dodic, Nerina; Dumaitre, Bernard; Daugan, Alain; Pianetti, Pascal
Journal of Medicinal Chemistry, 1995 , vol. 38, # 13 p. 2418 - 2426
反应条件
1: K2CO3 / H2O; tetrahydrofuran / 12 h / 50 °C 2: H2 / palladium on carbon / ethanol / 2585.7 Torr View Scheme
参考文献
Clark; Davenport
Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 1 p. 18 - 20
反应条件
potassium carbonate in tetrahydrofuran; water T=50°C; 12 h;
参考文献
Journal of Pharmaceutical Sciences, , vol. 76, # 1 p. 18 - 20
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
LECTUS THERAPEUTICS LIMITED; EDWARDS, Simon David; KIMBERLY, Meriel Ruth; ARMER, Richard Edward; KHAN, Nawaz Mohammed
Patent: WO2010/10380 A1, 2010 ;
Location in patent: Page/Page column 51 ;
WO 2010/010380 A1
反应条件
1: benzene 2: potassium sulfide; xylene; phosphorus pentasulfide / 80 °C 3: alcohol; hydrochloric acid / Electrolysis.an Bleielektroden 4: diluted sulfuric acid / durch Diazotieren View Scheme
参考文献
Kindler
Justus Liebigs Annalen der Chemie, 1923 , vol. 431, p. 213
Chem. Zentralbl., 1923 , vol. 94, # II p. 403
反应条件
(i) Mg, (ii) /BRN= 977162/, (iii) H2SO4, aq. AcOH; Multistep reaction;
参考文献
Langhals, Heinz; Range, Guenter; Wistuba, Eckehardt; Ruechardt, Christoph
Chemische Berichte, 1981 , vol. 114, # 12 p. 3813 - 3830
反应条件
1: benzene / anschliessendes Behandeln mit wss. Ammoniak 2: sulfuric acid 3: water View Scheme
参考文献
Soliman; West
Journal of the Chemical Society, 1944 , p. 53
反应条件
Yield given. Multistep reaction;
参考文献
Striegel; Mayer; Wiegrebe; Schlunegger; Siegrist; Aebi
Archiv der Pharmazie, 1992 , vol. 325, # 12 p. 751 - 760
反应条件
bromine Erwaermen des Reaktionsprodukts mit wss. Natriumhydrogencarbonat-Loesung;
参考文献
Fredga; Andersson
Arkiv foer Kemi, 1941 , vol. 14 B, # 38 p. 6
