2-(4-硝基苯基)乙酰氯合成路线 （共 63 条）
反应条件
sodium hydrogencarbonate; benzene
参考文献
Ismailski; Smirnov
Doklady Akademii Nauk SSSR, 1938 , vol. 20, p. 675,678
反应条件
lithium borohydride in tetrahydrofuran 1 h; Ambient temperature; Yield given;
参考文献
Herbert, Richard B.; Knaggs, Andrew R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 1 p. 109 - 114
反应条件
1: K2CO3 / H2O; tetrahydrofuran / 12 h / 50 °C 2: H2 / palladium on carbon / ethanol / 2585.7 Torr View Scheme
参考文献
Clark; Davenport
Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 1 p. 18 - 20
反应条件
1: 67 percent / sodium carbonate / H2O; benzene / 5 h / Ambient temperature 2: tert-butyl hypochlorite / CH2Cl2 / 0.33 h / 0 °C 3: 56 percent / Ag2CO3, trifluoroacetic acid / 0.5 h / 0 °C View Scheme
参考文献
Kawase, Masami; Kitamura, Takahiro; Kikugawa, Yasuo
Journal of Organic Chemistry, 1989 , vol. 54, # 14 p. 3394 - 3403
反应条件
1: water; N,N-dimethyl-formamide; toluene 2: Eaton’s reagent / 80 °C 3: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 2 h / 1034.32 Torr View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
反应条件
1: CH2Cl2 / 1 h / 40 °C 2: 1.) NaNH2 / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min 3: H20, ethan. KOH / ethanol / 24 h / Heating View Scheme
参考文献
Gualtieri; Conti; Dei; Giovannoni; Nannucci; Romanelli; Scapecchi; Teodori; Fanfani; Ghelardini; Giotti; Bartolini
Journal of Medicinal Chemistry, 1994 , vol. 37, # 11 p. 1704 - 1711
反应条件
1: water; N,N-dimethyl-formamide; toluene 2: Eaton’s reagent / 80 °C View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
反应条件
1: 1.) pyridine / 1.) CH2Cl2, RT, 1 h, 2.) reflux, 1 h 2: 2.) Et3N / 1.) benzene, RT, 3 h, 2.) n-BuOH, reflux, 40 min 3: 74.4 percent / SeO2 / dioxane; H2O / 4 h / Heating 4: 92.2 percent / aq. NaOH / ethanol / 0.17 h / 40 °C 5: thionyl chloride, DMF / CH2Cl2 / 2 h 6: CH2Cl2 / 0.5 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 6 p. 1279 - 1285
反应条件
1: 89 percent / aq. NaHCO3 / CH2Cl2 / 1 h 2: p-TsOH / toluene / 5 h / Heating 3: NaBH4 / methanol / 0.75 h 4: 1.) BH3, 2.) aq. HCl / 1.) THF, reflux, 2 h, 2.) MeOH, reflux, 1 h 5: 79 percent / toluene / 3 h / Heating 6: 3.30 g / H2 / 5percent Pd/C / ethanol / 1.5 h / 2068.6 Torr View Scheme
参考文献
Burke Jr.; Bajwa; Jacobson; Rice; Streaty; Klee
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1570 - 1574
反应条件
phosphorus pentachloride
T=100°C; 0.166667 h;
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; CASALE, Elena; CASUSCELLI, Francesco; DALVIT, Claudio; POLUCCI, Paolo; ZUCCOTTO, Fabio
Patent: WO2011/29775 A1, 2011 ;
Location in patent: Page/Page column 17 ;
