2-(4-硝基苯基)乙酰氯合成路线 （共 63 条）
反应条件
1: water; N,N-dimethyl-formamide; toluene
2: Eaton’s reagent / 80 °C
3: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 2 h / 1034.32 Torr
4: potassium carbonate / acetone / 7 h / Reflux
View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
反应条件
aluminium trichloride in dichloromethane
T=0°C;
参考文献
Ruehl, Wolfgang; Boelsing, Friedrich; Hofer, Edgar
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 11 p. 1487 - 1491
参考文献
Clark; Davenport
Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 1 p. 18 - 20
反应条件
1.1: LDA / tetrahydrofuran / 1 h / -78 °C
1.2: 78 percent / tetrahydrofuran / -78 - 20 °C
2.1: 65 percent / DIBAH / diethyl ether / -78 - 20 °C
View Scheme
参考文献
Katz, Christopher E.; Aube, Jeffrey
Journal of the American Chemical Society, 2003 , vol. 125, # 46 p. 13948 - 13949
反应条件
pyridine in dichloromethane
T=0 - 20°C; 4 h;
参考文献
Ishikawa, Fumihiro; Tsumuraya, Takeshi; Fujii, Ikuo
Journal of the American Chemical Society, 2009 , vol. 131, p. 456 - 457
反应条件
1: AlCl3 / 0.75 h / 20 °C
2: 76 percent / SeO2 / dimethylsulfoxide / 0.01 h / microwave irradiation
View Scheme
参考文献
Tatsugi, Jiro; Izawa, Yasuji
Journal of Chemical Research, Miniprint, 1988 , # 11 p. 2747 - 2763
反应条件
1: benzene
2: potassium sulfide; xylene; phosphorus pentasulfide / 80 °C
3: alcohol; hydrochloric acid / Electrolysis.an Bleielektroden
View Scheme
参考文献
Kindler
Justus Liebigs Annalen der Chemie, 1923 , vol. 431, p. 213
Chem. Zentralbl., 1923 , vol. 94, # II p. 403
反应条件
hydrazine in dichloromethane
T=20°C; 18 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/75567 A1, 2007 ;
Location in patent: Page/Page column 88-89 ;
WO 2007/075567 A1
反应条件
1: (i) Mg, (ii) /BRN= 977162/, (iii) H2SO4, aq. AcOH
2: NaH
View Scheme
参考文献
Stang,P.J.; Dueber,T.E.
Journal of the American Chemical Society, 1977 , vol. 99, # 8 p. 2602 - 2610
反应条件
1: 100 °C
2: aqueous ammonia
View Scheme
参考文献
Basterfield; Greig
Canadian Journal of Research, 1933 , vol. 8, p. 453
Chem. Zentralbl., 1933 , vol. 104, # II p. 1021
