1-苄基-2,5-二甲基吡咯合成路线 （共 4 条）
反应条件
hydrogenchloride in ethanol T=120°C; 0.166667 h; Microwave irradiation;
参考文献
Walia, Amit; Kang, Soosung; Silverman, Richard B
Journal of Organic Chemistry, 2013 , vol. 78, # 21 p. 10931 - 10937
反应条件
in various solvent(s) T=110°C; pH=3;
参考文献
Zamora, Rosario; Hidalgo, Francisco J.
Synlett, 2006 , # 9 p. 1428 - 1430
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=20°C; 0.25 h; Inert atmosphere;
2: 1-benzyl-2,5-dimethyl-1H-pyrrole T=100°C; Vilsmeier-Haack Formylation; 3 h; Inert atmosphere;
参考文献
Murugesan, Dinakaran; Mital, Alka; Kaiser, Marcel; Shackleford, David M.; Morizzi, Julia; Katneni, Kasiram; Campbell, Michael; Hudson, Alan; Charman, Susan A.; Yeates, Clive; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2975 - 2990
反应条件
1: POCl3 / 2 h / 100 °C
2: 30percent aq. NaOH
View Scheme
参考文献
Gangjee, Aleem; Patel, Jasmin; Kisliuk, Roy L.; Gaumont, Yvette
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3678 - 3685
