1-(4-氯苯基)-2,5-二甲基吡咯合成路线 （共 7 条）
反应条件
gallium trifluoromethanesulfonate in neat(no solvent) T=30°C; Paal-Knorr condensation; 0.5 h;
参考文献
Murugesan, Dinakaran; Mital, Alka; Kaiser, Marcel; Shackleford, David M.; Morizzi, Julia; Katneni, Kasiram; Campbell, Michael; Hudson, Alan; Charman, Susan A.; Yeates, Clive; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2975 - 2990
反应条件
indium; acetic acid in toluene T=80°C; 6 h; Inert atmosphere;
参考文献
Lee, Hyunseung; Kim, Byeong Hyo
Tetrahedron, 2013 , vol. 69, # 32 p. 6698 - 6708
反应条件
1: hex-3-yne-2,5-diol With ruthenium(II)-carbonyl-tris(triphenylphosphine) dihydride; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene 0.5 h; Inert atmosphereReflux; 2: 4-chloro-aniline in toluene 23.5 h; Inert atmosphereReflux;
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Taylor, James E.; Whittlesey, Michael K.; Williams, Jonathan M.J.
Tetrahedron, 2009 , vol. 65, # 44 p. 8981 - 8986
反应条件
T=140°C; 20 h; Further byproducts given;
参考文献
Benati, Luisa; Montevecchi, Pier Carlo; Toselli, Maurizio; Spagnolo, Piero
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1859 - 1864
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=20°C; 0.25 h; Inert atmosphere; 2: 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole T=100°C; Vilsmeier-Haack Formylation; 3 h; Inert atmosphere;
参考文献
Murugesan, Dinakaran; Mital, Alka; Kaiser, Marcel; Shackleford, David M.; Morizzi, Julia; Katneni, Kasiram; Campbell, Michael; Hudson, Alan; Charman, Susan A.; Yeates, Clive; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2975 - 2990
反应条件
water; acetic acid
T=50°C; 3 h;
参考文献
Porretta; Biava; Fioravanti; Villa; Simonetti
Farmaco, 1991 , vol. 46, # 7-8 p. 987 - 995
反应条件
1: chloroacetyl chloride With AlCl3, aluminium chloride in 1,2-dichloro-ethane
T=0°C; 0.5 h;
2: 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole in 1,2-dichloro-ethane
T=0 - 20°C; 2 h;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; FINLEY, Daniel; KING, Randall, W.; LEE, Byung-Hoon; LEE, Min, Jae; GAHMAN, Timothy, C.
Patent: WO2011/94545 A2, 2011 ;
Location in patent: Page/Page column 71 ;
WO 2011/094545 A1
