1',2',3',6'-四氢-[2,4']联吡啶合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Kamei, Katsuhide; Maeda, Noriko; Nomura, Kayoko; Shibata, Makoto; Katsuragi-Ogino, Ryoko; Koyama, Makoto; Nakajima, Mika; Inoue, Teruyoshi; Ohno, Tomochika; Tatsuoka, Toshio
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1978 - 1992
反应条件
trifluoroacetic acid in dichloromethane
T=0°C; 0.0833333 h;
参考文献
Saari, Walfred S.; Halczenko, Wasyl; Huff, Joel R.; Guare, James P.; Hunt, Cecilia A.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1182 - 1185
反应条件
1: 1.) n-BuLi / 1.) Et2O, hexane, -50 deg C, 10 min, 2.) Et2O, hexane, -30 deg C, 1 h
2: 45 percent / methyl ester of (carboxysulfamoyl)triethylammonium hydroxide inner salt / benzene / 0.75 h / 50 °C
3: 92 percent / TFA / CH2Cl2 / 0.08 h / 0 °C
View Scheme
参考文献
Saari, Walfred S.; Halczenko, Wasyl; Huff, Joel R.; Guare, James P.; Hunt, Cecilia A.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1182 - 1185
反应条件
1: 63 percent / Et3N / dimethylformamide / 18 h / Ambient temperature
2: 1.) n-BuLi / 1.) Et2O, hexane, -50 deg C, 10 min, 2.) Et2O, hexane, -30 deg C, 1 h
3: 45 percent / methyl ester of (carboxysulfamoyl)triethylammonium hydroxide inner salt / benzene / 0.75 h / 50 °C
4: 92 percent / TFA / CH2Cl2 / 0.08 h / 0 °C
View Scheme
参考文献
Saari, Walfred S.; Halczenko, Wasyl; Huff, Joel R.; Guare, James P.; Hunt, Cecilia A.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1182 - 1185
反应条件
1: 1.) n-BuLi / 1.) Et2O, hexane, -50 deg C, 10 min, 2.) Et2O, hexane, -30 deg C, 1 h
2: 45 percent / methyl ester of (carboxysulfamoyl)triethylammonium hydroxide inner salt / benzene / 0.75 h / 50 °C
3: 92 percent / TFA / CH2Cl2 / 0.08 h / 0 °C
View Scheme
参考文献
Saari, Walfred S.; Halczenko, Wasyl; Huff, Joel R.; Guare, James P.; Hunt, Cecilia A.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1182 - 1185
反应条件
1: 45 percent / methyl ester of (carboxysulfamoyl)triethylammonium hydroxide inner salt / benzene / 0.75 h / 50 °C
2: 92 percent / TFA / CH2Cl2 / 0.08 h / 0 °C
View Scheme
参考文献
Saari, Walfred S.; Halczenko, Wasyl; Huff, Joel R.; Guare, James P.; Hunt, Cecilia A.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1182 - 1185
