4-吡啶-2-基哌啶-4-醇合成路线 （共 5 条）
参考文献
Synaptic Pharmaceutical Corporation
Patent: US6274585 B1, 2001 ;
US 6274585 B1
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Abreo, Melwyn A.; Meng, Jerry J.; Agree, Charles S.
Patent: US2002/65292 A1, 2002 ;
反应条件
1.1: BuLi / tetrahydrofuran; hexane / cooling 1.2: tetrahydrofuran; hexane / cooling 2.1: trifluoroacetic acid / CH2Cl2 View Scheme
参考文献
Kamei, Katsuhide; Maeda, Noriko; Nomura, Kayoko; Shibata, Makoto; Katsuragi-Ogino, Ryoko; Koyama, Makoto; Nakajima, Mika; Inoue, Teruyoshi; Ohno, Tomochika; Tatsuoka, Toshio
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1978 - 1992
反应条件
1.1: BuLi / tetrahydrofuran; hexane / cooling 1.2: tetrahydrofuran; hexane / cooling 2.1: trifluoroacetic acid / CH2Cl2 View Scheme
参考文献
Kamei, Katsuhide; Maeda, Noriko; Nomura, Kayoko; Shibata, Makoto; Katsuragi-Ogino, Ryoko; Koyama, Makoto; Nakajima, Mika; Inoue, Teruyoshi; Ohno, Tomochika; Tatsuoka, Toshio
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1978 - 1992
反应条件
conc HCl; Ki; ammonia; potassium carbonate in tetrahydrofuran; methanol; water; acetone
参考文献
Synaptic Pharmaceutical Corporation
Patent: US6274585 B1, 2001 ;
US 6274585 B1
