3-[4-(苄氧基)苯基]丙酸合成路线 （共 27 条）
反应条件
1: 0.603 g / NaH / paraffin; dimethylformamide / 3 h / Ambient temperature 2: 0.370 g / KON / ethanol; H2O / 3 h / Heating 3: 0.249 g / 150 - 160 °C / 15 - 20 Torr View Scheme
参考文献
Ishii, Hisashi; Ishikawa, Tsutomu; Tohojoh, Toshiaki; Murakami, Keiko; Kawanable, Eri; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 9 p. 2051 - 2058
反应条件
T=150 - 160°C; P=15 - 20 Torr;
参考文献
Ishii, Hisashi; Ishikawa, Tsutomu; Tohojoh, Toshiaki; Murakami, Keiko; Kawanable, Eri; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 9 p. 2051 - 2058
反应条件
1: 0.370 g / KON / ethanol; H2O / 3 h / Heating 2: 0.249 g / 150 - 160 °C / 15 - 20 Torr View Scheme
参考文献
Ishii, Hisashi; Ishikawa, Tsutomu; Tohojoh, Toshiaki; Murakami, Keiko; Kawanable, Eri; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 9 p. 2051 - 2058
反应条件
sodium hydroxide; triphenylphosphine; diethylazodicarboxylate 1.) THF, 1 h; 2.) 10 min; Yield given. Multistep reaction;
参考文献
Krchnak, Viktor; Flegelova, Zuzka; Weichsel, Aleksandra S.; Lebl, Michal
Tetrahedron Letters, 1995 , vol. 36, # 35 p. 6193 - 6196
参考文献
Cevasco, Giorgio; Thea, Sergio
Gazzetta Chimica Italiana, 1997 , vol. 127, # 5 p. 269 - 272
反应条件
Yield given. Multistep reaction;
参考文献
Kuchar; Rejholec; Brunova; et al.
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2514 - 2524
反应条件
1,2-dichloro-ethane in hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US5169952 A1, 1992 ;
US 5169952 A
反应条件
1: 94 percent / DCC / DMAP / CH2Cl2 / 12 h / 20 °C 2: DIBAL-H / -78 °C 3: DMAP; pyridine; DIBAL-H / CH2Cl2; hexane / -78 - 0 °C 4: 84 percent / SnBr4 / CH2Cl2 / 1.3 h / -78 °C 5: K2CO3 / methanol / 3 h / Heating 6: 217 mg / K2CO3 / acetone / 12 h 7: 86 percent / Bu3SnH; AIBN / toluene / 0.25 h / Heating 8: 72 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / 7 h / 20 °C View Scheme
参考文献
Marumoto, Shinji; Jaber, James J; Vitale, Justin P; Rychnovsky, Scott D
Organic letters, 2002 , vol. 4, # 22 p. 3919 - 3922
反应条件
lithium aluminium tetrahydride in diethyl ether Heating;
参考文献
Wasikiewicz; Rokicki; Kielkiewicz; Paulus; Boehmer
Monatshefte fur Chemie, 1997 , vol. 128, # 8-9 p. 863 - 879
反应条件
1: 1.663 g / diethyl ether / 2 h / Ambient temperature 2: 1.305 g / LiAlH4 / diethyl ether; tetrahydrofuran / 1.) room temperature, 1 h, 2.) reflux, 1 h 3: 0.149 g / H2 / 10percent Pd-charcoal / ethanol / Ambient temperature View Scheme
参考文献
Henley-Smith, Peter; Whiting, Donald A.; Wood, Andrew F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 614 - 622
