1,2-苯并异恶唑-3-乙腈合成路线 （共 8 条）
反应条件
in water; acetonitrile
T=40°C;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
反应条件
trichlorophosphate
1.5 h; Heating;
参考文献
Uno; Kurokawa; Natsuka; et al.
Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 4 p. 632 - 643
反应条件
in ethanol; water
T=60°C; 1 h;
参考文献
Mohareb, Rafat Milad; Sherif, Sherif Mourad; Shams, Hoda Zaki; El-Torgoman, Abdel Moneim
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1990 , vol. 45, # 7 p. 1067 - 1071
反应条件
1: 80 percent / NH2OH*HCl / methanol / Ambient temperature
2: 72 percent / ethanol; H2O / 1 h / 60 °C
View Scheme
参考文献
Mohareb, Rafat Milad; Sherif, Sherif Mourad; Shams, Hoda Zaki; El-Torgoman, Abdel Moneim
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1990 , vol. 45, # 7 p. 1067 - 1071
反应条件
1: potassium carbonate; N-chloro-succinimide / tetrahydrofuran / 10 h / 20 °C
2: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 10 h / |Reflux
3: acetonitrile; water / 40 °C
View Scheme
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
反应条件
1: ammonia / methanol / 12 h / 20 °C
2: potassium carbonate; N-chloro-succinimide / tetrahydrofuran / 10 h / 20 °C
3: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 10 h / |Reflux
4: acetonitrile; water / 40 °C
View Scheme
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 10 h / |Reflux
2: acetonitrile; water / 40 °C
View Scheme
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
反应条件
1: (i) HCl, MeOH, (ii) NH3
2: POCl3 / 1.5 h / Heating
View Scheme
参考文献
Uno; Kurokawa; Natsuka; et al.
Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 4 p. 632 - 643
