2-溴-5-(三氟甲基)吡啶合成路线 （共 19 条）
反应条件
trimethylsilyl bromide in various solvent(s) 20 h; Heating;
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
反应条件
potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide T=25°C; 6 h;
参考文献
Cottet, Fabrice; Schlosser, Manfred
European Journal of Organic Chemistry, 2002 , # 2 p. 327 - 330
反应条件
1.1: nBuLi / hexane; diethyl ether / 0.75 h / -75 °C 1.2: 84 percent / I2 / hexane; tetrahydrofuran; diethyl ether / 0.75 h / -75 °C 2.1: 29 percent / KF; CuI / dimethylformamide; 1-methyl-pyrrolidin-2-one / 6 h / 25 °C View Scheme
参考文献
Cottet, Fabrice; Schlosser, Manfred
European Journal of Organic Chemistry, 2002 , # 2 p. 327 - 330
反应条件
potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); biphenyl-2-yl-di-tert-butyl-phosphane in N,N-dimethyl-formamide T=100°C; 12 h; Inert atmosphere;
参考文献
Blakemore, David C.; Marples, Louise A.
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4192 - 4195
反应条件
potassium fluoride; mono(bis(di-tert-butyl(4-(dimethylamino)phenyl)phosphonio)palladium(II))dichloride; water in N,N-dimethyl-formamide T=90°C; 12 h; Inert atmosphere;
参考文献
Blakemore, David C.; Marples, Louise A.
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4192 - 4195
反应条件
C60H48Cl2FeP4; Zn(C6H4-4-OMe)2 in tetrahydrofuran; toluene T=115°C; Suzuki coupling; 16 h; Inert atmosphere;
参考文献
Bedford, Robin B.; Hall, Mark A.; Hodges, George R.; Huwe, Michael; Wilkinson, Mark C.
Chemical Communications, 2009 , # 42 p. 6430 - 6432
反应条件
hydrogenchloride; sec.-butyllithium in diethyl ether; N,N-dimethyl acetamide
参考文献
ROHM AND HAAS COMPANY
Patent: EP955291 A1, 1999 ;
反应条件
n-butyllithium in toluene T=-75°C; 2 h;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1559 - 1568
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 80 °C / 11251.1 Torr 2: sodium tetrahydroborate; methanol / 0 - 20 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, IV, Siegfried Benjamin; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing; LIN, Xiaojuan; XU, Shanli; LV, Maoyun; YAO, Chen; LI, Lei; HUANG, Xing; GAO, Min
Patent: WO2013/166621 A1, 2013 ;
