2-溴-5-(三氟甲基)吡啶合成路线 （共 19 条）
反应条件
in dimethyl sulfoxide T=180°C; 2 h;
参考文献
Lee, Chih-Hung; Bayburt, Erol K.; DiDomenico, Stanley; Drizin, Irene; Gomtsyan, Arthur R.; Koenig, John R.; Perner, Richard J.; Schmidt, Robert G.; Turner, Sean C.; Jinkerson, Tammie K.; Zheng, Guo Zhu
Patent: US2005/113576 A1, 2005 ;
Location in patent: Page/Page column 68 ;
US 20050113576 A1
反应条件
in dimethyl sulfoxide
参考文献
Abbott Laboratories
Patent: US6933311 B2, 2005 ;
反应条件
hydrazine hydrate in ethanol T=20 - 90°C;
参考文献
AGIOS PHARMACEUTICALS, INC.; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.
Patent: WO2010/118063 A2, 2010 ;
Location in patent: Page/Page column 113 ;
WO 2010/118063 A2
反应条件
copper(I) oxide; potassium carbonate; ammonium hydroxide; N,N-dimethylethylenediamine in ethylene glycol T=60°C; 16 h; Inert atmosphere;
参考文献
Elmkaddem, Mohammed K.; Fischmeister, Cedric; Thomas, Christophe M.; Renaud, Jean-Luc
Chemical Communications, 2010 , vol. 46, # 6 p. 925 - 927
反应条件
triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct T=80°C; P=3102.97 Torr; 3 h;
参考文献
US2009/124666 A1, ;
Page/Page column 25 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine T=80°C; P=11251.1 Torr;
参考文献
WO2013/166621 A1, ;
Page/Page column 48 ;
参考文献
Li, Changkun; Yano, Takaaki; Ishida, Naoki; Murakami, Masahiro
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9801 - 9804
Angew. Chem., 2013 , vol. 125, # 37 p. 9983 - 9986
反应条件
potassium carbonate in tetrahydrofuran
T=100°C; 16 h; Sealed tube;
参考文献
IRM LLC; NOVARTIS AG; CHATTERJEE, Arnab Kumar; NAGLE, Advait Suresh; PARASELLI, Prasuna; KONDREDDI, Ravinder Reddy; LEONG, Seh Yong; MISHRA, Pranab Kumar; MOREAU, Robert Joseph; ROLAND, Jason Thomas; SIM, Wei Lin Sandra; SIMON, Oliver; TAN, Liying Jocelyn; YEUNG, Bryan KS; ZOU, Bin; BOLLU, Venkatataiah
Patent: WO2014/78802 A1, 2014 ;
Location in patent: Page/Page column 162 ;
参考文献
Hanss, David; Freys, Jonathan C.; Bernardinelli, Gerald; Wenger, Oliver S.
European Journal of Inorganic Chemistry, 2009 , # 32 p. 4850 - 4859
