氨基吡嗪合成路线

参考文献

Boehringer Ingelheim International GmbH; BYLOCK, Lars Anders
Patent: US2013/236468 A1, 2013 ;
Location in patent: Paragraph 0344 ;

5049-61-6氨基吡嗪+

65868-37-3乙基3-氯-2-氧代丙酸酯

77112-52-8咪唑并[1,2-a]吡嗪-2-甲酸乙酯

参考文献

Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212

5049-61-6氨基吡嗪

6270-63-92-羟基吡嗪

参考文献

Dutcher
Journal of Biological Chemistry, 1947 , vol. 171, p. 321,324

5049-61-6氨基吡嗪+

431-35-63-溴-1,1,1-三氟丙酮

109113-96-42-三氟甲基咪唑并[1,2-A]吡嗪

参考文献

ARES TRADING S.A.; JORAND-LEBRUN, Catherine; SWINNEN, Dominique; GERBER, Patrick; KULKARNI, Santosh
Patent: WO2012/130915 A1, 2012 ;
Location in patent: Page/Page column 74 ;
WO 2012/130915 A1

5049-61-6氨基吡嗪+

431-35-63-溴-1,1,1-三氟丙酮+

144-55-8碳酸氢钠

109113-96-42-三氟甲基咪唑并[1,2-A]吡嗪

参考文献

PFIZER LIMITED; PFIZER INC.
Patent: WO2004/29051 A1, 2004 ;
Location in patent: Page 43-44 ;
WO 2004/029051 A1

5049-61-6氨基吡嗪+

598-31-2溴丙酮

33668-80-3

参考文献

Gong, Leyi; Tan, Yun-Chou
Patent: US2011/301170 A1, 2011 ;
Location in patent: Page/Page column 23-24 ;

5049-61-6氨基吡嗪+

78-95-5一氯丙酮

33668-80-3

参考文献

Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212

5049-61-6氨基吡嗪+

106358-48-9

17114-78-2

参考文献

Terekhova, M. I.; Petrov, E. S.; Mikhaleva, M. A.; Shkurko, O. P.; Mamaev, V. P.; Shatenshtein, A. I.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 6 - 10
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 1 p. 9 - 14

5049-61-6氨基吡嗪+

600-22-6

16298-03-6

参考文献

Vontor, Tomas; Palat, Karel; Lycka, Antonin
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 5 p. 1306 - 1310

5049-61-6氨基吡嗪+

104-94-9

119738-50-0

参考文献

Xue, Dong; Jia, Zhi-Hui; Zhao, Cong-Jun; Zhang, Yan-Yan; Wang, Chao; Xiao, Jianliang
Chemistry - A European Journal, 2014 , vol. 20, # 10 p. 2960 - 2965