3-氯-2-甲基-3-氧代丙酸乙酯合成路线 （共 8 条）
参考文献
Marguery
Bulletin de la Societe Chimique de France, 1905 , vol. <3> 33, p. 550
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1479384 A1, 2004 ;
参考文献
Marguery
Bulletin de la Societe Chimique de France, 1905 , vol. <3> 33, p. 550
反应条件
thionyl chloride
T=40°C; 4 h;
参考文献
Danieli, Bruno; Lesma, Giordano; Palmisano, Giovanni; Passarella, Daniele; Silvani, Alessandra
Tetrahedron, 1994 , vol. 50, # 23 p. 6941 - 6954
反应条件
hydrogenchloride; potassium tert-butylate in tetrahydrofuran; water
参考文献
Tokunaga, Teruhisa; Hume, William Ewan; Kitoh, Makoto; Nagata, Ryu
Patent: US2003/181496 A1, 2003 ;
反应条件
in N,N-dimethyl-formamide
5 h; Heating;
参考文献
Ukrainets, Igor V.; Bezugly, Peter A.; Treskach, Vladimir I.; Taran, Svetlana G.; Gorokhova, Olga V.
Tetrahedron, 1994 , vol. 50, # 34 p. 10331 - 10338
反应条件
(i) KOH, EtOH, (ii) SOCl2; Multistep reaction;
参考文献
Holmquist,B.; Bruice,T.C.
Journal of the American Chemical Society, 1969 , vol. 91, p. 2993 - 3002
参考文献
Aebli; Grob
Helvetica Chimica Acta, 1957 , vol. 40, p. 2185,2190
