高哌嗪合成路线 - 魔法化学

参考文献

ASTRAZENECA AB
Patent: US2008/153812 A1, 2008 ;
Location in patent: Page/Page column 140; 149-150 ;
US 20080153812 A1

参考文献

Burgess, Steven J.; Kelly, Jane X.; Shomloo, Shawheen; Wittlin, Sergio; Brun, Reto; Liebmann, Katherine; Peyton, David H.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6477 - 6489

505-66-8高哌嗪+

1194-02-1对氟苯腈

232923-90-9

参考文献

Donkor, Isaac O.; Huang, Tien L.; Tao, Bin; Rattendi, Donna; Lane, Schennella; Vargas, Marc; Goldberg, Burt; Bacchi, Cyrus
Journal of Medicinal Chemistry, 2003 , vol. 46, # 6 p. 1041 - 1048

505-66-8高哌嗪+

32779-36-55-溴-2-氯嘧啶

849021-44-91-(5-溴吡啶)[1,4]二氮杂庚烷

参考文献

GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT
Patent: WO2009/120789 A1, 2009 ;
Location in patent: Page/Page column 119 ;

505-66-8高哌嗪+

109-09-12-氯吡啶

287114-32-3

参考文献

Proximagen Limited; Savory, Edward Daniel; Stewart, Allson; Cartey, Allison; Brown, Giles; Simpson, Iain; Oliver, Kathryn; Patient, Lee; Higginbottom, Michael; Cole, Andrew Graham
Patent: US2013/289020 A1, 2013 ;
Location in patent: Paragraph 0376; 0377 ;

505-66-8高哌嗪+

109-04-6邻溴吡啶

287114-32-3

参考文献

KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CHEMON INC.
Patent: WO2008/153325 A1, 2008 ;
Location in patent: Page/Page column 73 ;

参考文献

Nippon Shinyaku Co., Ltd.
Patent: EP1156045 A1, 2001 ;

Title/Abstract Full Text Show Details
Nippon Shinyaku Co., Ltd.
Patent: EP1243268 A1, 2002 ;

505-66-8高哌嗪+

591-50-4碘苯

61903-27-31-苯基-1,4-二氮杂环庚烷

参考文献

Komoto; Okada; Sato; Niino; Oka; Sakamoto
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 10 p. 1314 - 1320

505-66-8高哌嗪+

108-24-7乙酸酐

61903-11-5

参考文献

Tetrahedron Letters, , vol. 49, # 34 p. 5047 - 5049

505-66-8高哌嗪+

91-16-7邻苯二甲醚

参考文献

Hoeve, Wolter ten; Kruse, Chris, G.; Luteyn, Jan M.; Thiecke, Janet R. G.; Wynberg, Hans
Journal of Organic Chemistry, 1993 , vol. 58, # 19 p. 5101 - 5106