高哌嗪合成路线 - 魔法化学

505-66-8高哌嗪

112275-50-01,4-二氮杂环庚烷-1-甲酸叔丁酯

参考文献

American Home Products Corporation
Patent: US6337326 B1, 2002 ;
Location in patent: Page column 6 ;
US 6337326 B1

参考文献

Teijin Intellectual Property Center Limited; Combichem, Inc.
Patent: US6686353 B1, 2004 ;
Location in patent: Page/Page column 81-82 ;
US 6686353 B1

505-66-8高哌嗪+

1722-12-92-氯嘧啶

21279-57-21-(2-嘧啶基)高哌嗪

参考文献

Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300

505-66-8高哌嗪+

402-67-5间氟硝基苯

223797-01-11-(3-硝基苯基)-[1,4]二氮杂烷

参考文献

Neurosearch A/S
Patent: US2004/72823 A1, 2004 ;
Location in patent: Page/Page column 20 ;

505-66-8高哌嗪+

78060-54-52-氯喹啉-6-甲腈

676131-30-9

参考文献

Zhou, Dahui; Stack, Gary P.; Lo, Jennifer; Failli, Amedeo A.; Evrard, Deborah A.; Harrison, Boyd L.; Hatzenbuhler, Nicole T.; Tran, Megan; Croce, Susan; Yi, Soo; Golembieski, Jeannette; Hornby, Geoffrey A.; Lai, Margaret; Lin, Qian; Schechter, Lee E.; Smith, Deborah L.; Shilling, Adam D.; Huselton, Christine; Mitchell, Paul; Beyer, Chad E.; Andree, Terrance H.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 15 p. 4955 - 4959

505-66-8高哌嗪

84904-97-21,7-二氮杂双环[5.3.2]十二烷

参考文献

Alder, Roger W.; Eastment, Paul; Moss, Richard E.; Sessions, Richard B.; Stringfellow, Martin A.
Tetrahedron Letters, 1982 , vol. 23, # 40 p. 4181 - 4184

505-66-8高哌嗪+

106-89-8环氧氯丙烷

85095-78-9N(1),N(4)-二-(gamma-氯-beta-羟基丙基)六氢-1,4-二氮杂卓

参考文献

Nagababu, Penumaka; Maji, Suman; Kumar, Manyam Praveen; Chen, Peter P.-Y.; Yu, Steve S.-F.; Chan, Sunney I.
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 17 p. 3275 - 3282

505-66-8高哌嗪+

2315-36-8N,N-二乙基-2-氯乙酰胺

87055-46-7

参考文献

Teijin Intellectual Property Center Limited; Combichem, Inc.
Patent: US6686353 B1, 2004 ;
Location in patent: Page/Page column 106-107 ;
US 6686353 B1

505-66-8高哌嗪+

75-36-5乙酰氯+

2315-36-8N,N-二乙基-2-氯乙酰胺

87055-46-7

参考文献

TEIJIN LIMITED
Patent: EP914319 B1, 2001 ;
EP 0914319 B1

505-66-8高哌嗪+

329-59-94-氟-3-硝基苯甲酸甲酯

870998-07-5

参考文献

PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2007/2742 A1, 2007 ;
Location in patent: Page/Page column 33 ;
WO 2007/002742 A1