N-(2-氯乙基)吡咯烷合成路线 （共 21 条）
反应条件
thionyl chloride; chloroform
参考文献
Elz; Keller
Archiv der Pharmazie, 1995 , vol. 328, # 7-8 p. 585 - 594
反应条件
potassium carbonate in water
参考文献
Hickmott, Peter W.; Wood, Simon; Murray-Rust, Peter
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2033 - 2038
反应条件
in acetone 35 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 5 p. 773 - 780
反应条件
1: toluene 2: Raney nickel; ethanol / Hydrogenation View Scheme
参考文献
Biel; Di Pierro
Journal of the American Chemical Society, 1958 , vol. 80, p. 4609,4611
反应条件
sodium hydride in N,N-dimethyl-formamide T=50°C;
参考文献
Sano, Yoshiyuki; Nakata, Kenya; Otoyama, Takafumi; Umeda, Sei; Shiina, Isamu
Chemistry Letters, 2007 , vol. 36, # 1 p. 40 - 41
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; Heating overnight;
参考文献
Adir et Compagnie
Patent: US6339092 B1, 2002 ;
Location in patent: Page column 5 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 5 h;
参考文献
Ryckebusch, Adina; Garcin, Deborah; Lansiaux, Amelie; Goossens, Jean-Francois; Baldeyrou, Brigitte; Houssin, Raymond; Bailly, Christian; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2008 , vol. 51, # 12 p. 3617 - 3629
参考文献
TARGEGEN, INC.
Patent: WO2007/53452 A1, 2007 ;
Location in patent: Page/Page column 65 ;
WO 2007/053452 A1
反应条件
1: toluene 2: aqueous hydrochloric acid View Scheme
参考文献
Chiti; Selleri
Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 261,282
反应条件
sodium hydroxide; adogen 464 in tetrahydrofuran 6 h; Heating;
参考文献
Moore,G.G.; Hansen,J.C.
Journal of Fluorine Chemistry, 1986 , vol. 32, p. 41
