N-(2-氯乙基)吡咯烷合成路线 （共 21 条）
参考文献
Fakstorp; Christiansen
Acta Chemica Scandinavica (1947-1973), 1957 , vol. 11, p. 1698,1701
参考文献
Stoss; Peter; Satzinger; Gerhard; Herrmann; Manfred; Heldt; Wolfgang
Patent: US4294838 A1, 1981 ;
反应条件
potassium carbonate in acetonitrile
4 h; Heating;
参考文献
Bourgery, Guy; Dostert, Philippe; Lacour, Alain; Langlois, Michel; Pourrias, Bernard; Tisne-Versailles, Jacky
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 159 - 167
参考文献
Schuler,W.A.; Klebe,H.
Justus Liebigs Annalen der Chemie, 1962 , vol. 653, p. 172 - 180
反应条件
1: potassium carbonate / acetonitrile / 8 h / Reflux
2: trifluoroacetic acid / dichloromethane / 21 h / 0 - 20 °C
View Scheme
参考文献
Mohammed, Idrees; Parai, Maloy K.; Jiang, Xinpeng; Sharova, Natalia; Singh, Gatikrushna; Stevenson, Mario; Rana, Tariq M.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 6 p. 465 - 469
反应条件
sodium hydride
1.) dioxane, kerosene, r.t., 45 min, 2.) dioxane, 60 deg C, overnight; Yield given. Multistep reaction;
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
参考文献
Wright
Journal of the American Chemical Society, 1949 , vol. 71, p. 1028
参考文献
Moffett et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 1565,1566
反应条件
caesium carbonate in acetone
4 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/13134 A2, 2004 ;
Location in patent: Page 27 ;
WO 2004/013134 A2
反应条件
1: toluene
View Scheme
参考文献
Fakstorp; Christiansen
Acta Chemica Scandinavica (1947-1973), 1957 , vol. 11, p. 1698,1701
