5-(羟基甲基)吡啶甲酸乙酯合成路线 （共 14 条）
参考文献
SRI International
Patent: US4526787 A1, 1985 ;
反应条件
sodium tetrahydroborate; calcium chloride in ethanol
参考文献
Barth, Hubert; Burger, Guenther; Doepp, Heinrike; Kobayashi, Makoto; Musso, Hans
Liebigs Annalen der Chemie, 1981 , # 12 p. 2164 - 2179
反应条件
1: 67 percent / conc. H2SO4 / 16 h / Heating
2: 51 percent / NaBH4, CaCl2 / ethanol / 16 h / Ambient temperature
3: 59 percent / SeO2, H2O / dioxane / 3 h / 100 °C
4: 97 percent / 30percent H2O2 / H2O / 16 h / Ambient temperature
5: 1.) Et3N, CaCl2, 2.) H2SO4 / 1.) EtOH, 2.) reflux, 4 h
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
1: 59 percent / SeO2, H2O / dioxane / 3 h / 100 °C
2: 97 percent / 30percent H2O2 / H2O / 16 h / Ambient temperature
3: 1.) Et3N, CaCl2, 2.) H2SO4 / 1.) EtOH, 2.) reflux, 4 h
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
1: 51 percent / NaBH4, CaCl2 / ethanol / 16 h / Ambient temperature
2: 59 percent / SeO2, H2O / dioxane / 3 h / 100 °C
3: 97 percent / 30percent H2O2 / H2O / 16 h / Ambient temperature
4: 1.) Et3N, CaCl2, 2.) H2SO4 / 1.) EtOH, 2.) reflux, 4 h
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
1: 97 percent / 30percent H2O2 / H2O / 16 h / Ambient temperature
2: 1.) Et3N, CaCl2, 2.) H2SO4 / 1.) EtOH, 2.) reflux, 4 h
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
1: 71 percent / conc. H2SO4 / 14 h / Heating
2: 19 percent / N-bromosuccinimide, dibenzoylperoxide / CCl4 / 3 h / 60 - 80 °C / Irradiation
3: 84 percent
4: 57 percent / NaBH4, CaCl2 / ethanol
View Scheme
参考文献
Barth, Hubert; Burger, Guenther; Doepp, Heinrike; Kobayashi, Makoto; Musso, Hans
Liebigs Annalen der Chemie, 1981 , # 12 p. 2164 - 2179
反应条件
1: 19 percent / N-bromosuccinimide, dibenzoylperoxide / CCl4 / 3 h / 60 - 80 °C / Irradiation
2: 84 percent
3: 57 percent / NaBH4, CaCl2 / ethanol
View Scheme
参考文献
Barth, Hubert; Burger, Guenther; Doepp, Heinrike; Kobayashi, Makoto; Musso, Hans
Liebigs Annalen der Chemie, 1981 , # 12 p. 2164 - 2179
反应条件
1: SeO2
2: 71 percent / conc. H2SO4 / 14 h / Heating
3: 19 percent / N-bromosuccinimide, dibenzoylperoxide / CCl4 / 3 h / 60 - 80 °C / Irradiation
4: 84 percent
5: 57 percent / NaBH4, CaCl2 / ethanol
View Scheme
参考文献
Barth, Hubert; Burger, Guenther; Doepp, Heinrike; Kobayashi, Makoto; Musso, Hans
Liebigs Annalen der Chemie, 1981 , # 12 p. 2164 - 2179
反应条件
1: 84 percent
2: 57 percent / NaBH4, CaCl2 / ethanol
View Scheme
参考文献
Barth, Hubert; Burger, Guenther; Doepp, Heinrike; Kobayashi, Makoto; Musso, Hans
Liebigs Annalen der Chemie, 1981 , # 12 p. 2164 - 2179
