6-羟甲基-2-氰基吡啶合成路线 （共 11 条）
反应条件
potassium carbonate in methanol 2.5 h;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
methanol; sodium tetrahydroborate T=20°C; 0.5 h;
参考文献
Tsukamoto, Issei; Koshio, Hiroyuki; Kuramochi, Takahiro; Saitoh, Chikashi; Yanai-Inamura, Hiroko; Kitada-Nozawa, Chika; Yamamoto, Eisaku; Yatsu, Takeyuki; Shimada, Yoshiaki; Sakamoto, Shuichi; Tsukamoto, Shin-ichi
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 8 p. 3130 - 3141
反应条件
1: 98 percent / m-CPBA / CHCl3 / 0.5 h / 0 °C 2: 1.) N,N-dimethylcarbamoyl chloride / 1.) CH2Cl2, a) RT, 90 min, b) reflux, 90 min, 2.) CH2Cl2, reflux, 36 h View Scheme
参考文献
Bremberg, Ulf; Rahm, Fredrik; Moberg, Christina
Tetrahedron Asymmetry, 1998 , vol. 9, # 19 p. 3437 - 3443
反应条件
1: 1.) N,N-dimethylcarbamoyl chloride / 1.) CH2Cl2, a) RT, 90 min, b) reflux, 90 min, 2.) CH2Cl2, reflux, 36 h 2: 68 percent / aq. HF / acetonitrile View Scheme
参考文献
Bremberg, Ulf; Rahm, Fredrik; Moberg, Christina
Tetrahedron Asymmetry, 1998 , vol. 9, # 19 p. 3437 - 3443
反应条件
1: 42.79 g / 24 h / Ambient temperature 2: ethanol; H2O / 2.5 h / Ambient temperature 3: 92 percent / m-chloroperbenzoic acid / CHCl3 / Ambient temperature 4: 50 percent / Heating 5: 75 percent / K2CO3 / methanol / 2.5 h View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 92 percent / m-chloroperbenzoic acid / CHCl3 / Ambient temperature 2: 50 percent / Heating 3: 75 percent / K2CO3 / methanol / 2.5 h View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 50 percent / Heating 2: 75 percent / K2CO3 / methanol / 2.5 h View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: ethanol; H2O / 2.5 h / Ambient temperature 2: 92 percent / m-chloroperbenzoic acid / CHCl3 / Ambient temperature 3: 50 percent / Heating 4: 75 percent / K2CO3 / methanol / 2.5 h View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
N,N-dimethylcarbamoyl chloride 1.) CH2Cl2, a) RT, 90 min, b) reflux, 90 min, 2.) CH2Cl2, reflux, 36 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bremberg, Ulf; Rahm, Fredrik; Moberg, Christina
Tetrahedron Asymmetry, 1998 , vol. 9, # 19 p. 3437 - 3443
反应条件
phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide 1.5 h; Ambient temperature;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
