(1R,2r)-1-氨基-2,3-二氢-6-硝基-1H-茚-2-醇合成路线 （共 9 条）
反应条件
1: With hydrogenchloride in diethyl ether
T=20°C; 0.25 h;
2: With ammonium hydroxide in tetrahydrofuran
0.0833333 h;
参考文献
Kozhushkov, Sergei I.; Yufit, Dmitrii S.; De Meijere, Armin
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 2-3 p. 255 - 265
反应条件
sodium nitrate; trifluoroacetic acid; trifluoroacetic anhydride in dichloromethane
T=-20°C; 5 h; Large scale reaction;
参考文献
Hansen, Marvin M.; Borders, Sandra S.K.; Clayton, Marcella T.; Heath, Perry C.; Kolis, Stanley P.; Larsen, Samuel D.; Linder, Ryan J.; Reutzel-Edens, Susan M.; Smith, Justin C.; Tameze, Sheila L.; Ward, Jeffrey A.; Weigel, Leland O.
Organic Process Research and Development, 2009 , vol. 13, # 2 p. 198 - 208
反应条件
1.1: HNO3; H2SO4
1.2: CrO3; AcOH
2.1: 99 percent / NaBH4 / methanol
3.1: 100 percent / TsOH / toluene
4.1: PPNO; NaOCl; aq. NaH2PO4 / (S,S)-Mn-salen / CH2Cl2
5.1: NH4OH
View Scheme
参考文献
Gross, Michael F.; Beaudoin, Serge; McNaughton-Smith, Grant; Amato, George S.; Castle, Neil A.; Huang, Christine; Zou, Anruo; Yu, Weifeng
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2849 - 2853
反应条件
1: 99 percent / NaBH4 / methanol
2: 100 percent / TsOH / toluene
3: PPNO; NaOCl; aq. NaH2PO4 / (S,S)-Mn-salen / CH2Cl2
4: NH4OH
View Scheme
参考文献
Gross, Michael F.; Beaudoin, Serge; McNaughton-Smith, Grant; Amato, George S.; Castle, Neil A.; Huang, Christine; Zou, Anruo; Yu, Weifeng
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2849 - 2853
反应条件
1: PPNO; NaOCl; aq. NaH2PO4 / (S,S)-Mn-salen / CH2Cl2
2: NH4OH
View Scheme
参考文献
Gross, Michael F.; Beaudoin, Serge; McNaughton-Smith, Grant; Amato, George S.; Castle, Neil A.; Huang, Christine; Zou, Anruo; Yu, Weifeng
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2849 - 2853
反应条件
1: 100 percent / TsOH / toluene
2: PPNO; NaOCl; aq. NaH2PO4 / (S,S)-Mn-salen / CH2Cl2
3: NH4OH
View Scheme
参考文献
Gross, Michael F.; Beaudoin, Serge; McNaughton-Smith, Grant; Amato, George S.; Castle, Neil A.; Huang, Christine; Zou, Anruo; Yu, Weifeng
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2849 - 2853
反应条件
1: KNO3; H2SO4
2: 99 percent / NaBH4 / methanol
3: 100 percent / TsOH / toluene
4: PPNO; NaOCl; aq. NaH2PO4 / (S,S)-Mn-salen / CH2Cl2
5: NH4OH
View Scheme
参考文献
Gross, Michael F.; Beaudoin, Serge; McNaughton-Smith, Grant; Amato, George S.; Castle, Neil A.; Huang, Christine; Zou, Anruo; Yu, Weifeng
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2849 - 2853
反应条件
1: With hydrogenchloride
T=100°C; 1 h;
2: With ammonium hydroxide
T=20°C; 0.0833333 h;
参考文献
Kozhushkov, Sergei I.; Yufit, Dmitrii S.; De Meijere, Armin
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 2-3 p. 255 - 265
参考文献
Gross, Michael F.; Beaudoin, Serge; McNaughton-Smith, Grant; Amato, George S.; Castle, Neil A.; Huang, Christine; Zou, Anruo; Yu, Weifeng
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2849 - 2853
