3H-苯并[e]吲哚-2-羧酸合成路线 （共 7 条）
反应条件
potassium hydroxide; water in ethanol
T=80°C; 0.5 h;
参考文献
The Scripps Research Institute
Patent: US2005/26987 A1, 2005 ;
Location in patent: Page 31 ;
参考文献
The Upjohn Company
Patent: US5489593 A1, 1996 ;
参考文献
SCHERING CORPORATION
Patent: WO2008/82488 A1, 2008 ;
Location in patent: Page/Page column 129 ;
反应条件
1: EtONa
2: toluene / Heating
3: NaOH
View Scheme
参考文献
Miller, Thomas A.; Vachaspati, Prakash R.; Labroli, Marc A.; Thompson, Charles D.; Bulman, Amanda L.; Macdonald, Timothy L.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1065 - 1070
反应条件
zinc(II) chloride
T=195°C; Behandeln des entstandenen Aethylesters mit alkoh. Kalilauge;
参考文献
Schlieper
Justus Liebigs Annalen der Chemie, 1886 , vol. 236, p. 177
参考文献
Beugelmans, Rene; Chbani, Mohamed
Bulletin de la Societe Chimique de France, 1995 , vol. 132, # 7 p. 729 - 733
反应条件
quinoline; copper
Heating;
参考文献
Miller, Thomas A.; Vachaspati, Prakash R.; Labroli, Marc A.; Thompson, Charles D.; Bulman, Amanda L.; Macdonald, Timothy L.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1065 - 1070
