3-氨基-2-乙基-4(3H)-喹唑啉酮合成路线 （共 26 条）
反应条件
1: 75 percent / gl. acetic acid / ethanol / 5 h / Heating 2: 1) aq. NaNO2, gl. acetic acid, HCl / 1) 0-5 deg C, 2) pyridine, r.t., overnight View Scheme
参考文献
Singh, Shradha; Shukla, Mukundja; Srivastava, Vijai K.; Shanker, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 368 - 370
反应条件
lead(IV) acetate; trifluoroacetic acid var. alkenes; Product distribution;
参考文献
Atkinson, Robert S.; Darrah, Christine M.; Kelly, Brian J.
Tetrahedron Letters, 1987 , vol. 28, # 15 p. 1711 - 1712
反应条件
1: 80 percent / gl. acetic acid / ethanol / 5 h / Heating 2: 1) aq. NaNO2, gl. acetic acid, HCl / 1) 0-5 deg C, 2) pyridine, r.t., overnight View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 368 - 370
反应条件
1: CH2Cl2 / 0.08 h / -25 - -20 °C 2: 15 percent / CH2Cl2 / -25 - 20 °C View Scheme
参考文献
Atkinson, Robert S.; Edwards, Paul J.; Thomson, Gordon A.
Journal of the Chemical Society, Chemical Communications, 1992 , # 17 p. 1256 - 1257
反应条件
in dichloromethane N-acetoxyaminoquinazolone (prepd. in situ from aminoquinazolinone and acid-free Pb(OAc)4 at -25°C) in CH2Cl2 is stirred for 30 min at -25°C; addn. of alkenylstannane, warming to ambient temp.; Pb(OAc)2 is filtered off, washed with NaHCO3 soln. and H2O, dried, evapd., chromy. (silica, ethyl acatate-light petroleum) yields Sn-compd., elem. anal.;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry, , p. 1657 - 1662
反应条件
in dichloromethane N-acetoxyaminoquinazolone (prepd. in situ from aminoquinazolinone and acid-free Pb(OAc)4 at -25°C) in CH2Cl2 is stirred for 30 min at -25°C; addn. of alkenylstannane, warming to ambient temp.; Pb(OAc)2 is filtered off, washed with NaHCO3 soln. and H2O, dried, evapd., chromy. (silica, ethyl acatate-light petroleum) yields Sn-compd. Further elution yield bezoxazin, elem. anal.;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry, , p. 1657 - 1662
参考文献
Karabuga, Semistan; Kazaz, Cavit; Kilic, Hamdullah; Ulukanli, Sabri; Celik, Ayhan
Tetrahedron Letters, 2005 , vol. 46, # 31 p. 5225 - 5227
反应条件
in chloroform-d1 T=-20°C; Title compound not separated from byproducts;
参考文献
Atkinson, Robert S.; Kelly, Brian J.
Journal of the Chemical Society, Chemical Communications, 1987 , # 18 p. 1362 - 1363
反应条件
lead(IV) acetate in dichloromethane 1 h; Ambient temperature; Yield given;
参考文献
Dickinson, Julia M.; Murphy, John A.
Tetrahedron, 1992 , vol. 48, # 7 p. 1317 - 1326
反应条件
lead(IV) acetate; acrylic acid methyl ester 1.) CH2Cl2, -25 to -20 deg C, 5 min, 2.) CH2Cl2, -25 deg C to room temp., 25 min; Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Atkinson, Robert S.; Ulukanli, Sabri
Journal of the Chemical Society. Perkin Transactions 2, 1999 , # 4 p. 771 - 776
