6-甲氧基苯并呋喃-2-羧酸合成路线 （共 13 条）
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=20°C; 3 h; 2: With hydrogenchloride in water
参考文献
AKAAL PHARMA PTY LTD; GILL, Gurmit S; GROBELNY, Damian W
Patent: WO2010/43000 A1, 2010 ;
Location in patent: Page/Page column 94 ;
WO 2010/043000 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=140°C; 4 h;
参考文献
Jackson, Yvette A.; Marriott, Karla-Sue C.
Molecules, 2002 , vol. 7, # 3 p. 353 - 362
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=20°C; 3 h;
参考文献
AKAAL PHARMA PTY LTD; GROBELNY, Damian W; GILL, Gurmit S
Patent: WO2014/63199 A1, 2014 ;
Location in patent: Page/Page column 33 ;
反应条件
potassium hydroxide; potassium carbonate in ethanol; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235771 B1, 2001 ;
反应条件
1: K2CO3 / butan-2-one / 7 h / Heating 2: 1N aq. NaOH / methanol / 1 h / Heating View Scheme
参考文献
Chapleo, Christopher B.; Myers, Peter L.; Butler, Richard C. M.; Davis, John A.; Doxey, John C.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 570 - 576
反应条件
potassium carbonate; butanone Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge;
参考文献
Tanaka
Journal of the American Chemical Society, 1951 , vol. 73, p. 872
反应条件
trichlorophosphate T=100°C; 15 h; Further byproducts given. Yields of byproduct given;
参考文献
Hirota, Takashi; Fujita, Hiroko; Sasaki, Kenji; Namba, Tetsuto; Hayakawa, Shohei
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 1347 - 1351
反应条件
trichlorophosphate T=100°C; 15 h; Further byproducts given. Yields of byproduct given;
参考文献
Hirota, Takashi; Fujita, Hiroko; Sasaki, Kenji; Namba, Tetsuto; Hayakawa, Shohei
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 1347 - 1351
反应条件
1.1: N-bromosuccinmide / acetonitrile / 0.08 h / 80 °C / Microwave irradiation 2.1: sodium hydroxide / ethanol / 0.08 h / 79 °C / Microwave irradiation 2.2: pH 1 View Scheme
参考文献
Marriott, Karla-Sue C.; Bartee, Rena; Morrison, Andrew Z.; Stewart, Leonard; Wesby, Julian
Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3319 - 3321
反应条件
1: sodium ethylate; ethanol 2: aq.-ethanolic KOH-solution View Scheme
参考文献
McGookin et al.
Journal of the Chemical Society, 1940 , p. 787,791
