1: 86 percent / N-methylmorpholine, isobutyl chlorocarbonate, triethylamine / dimethylformamide / 1) 1h, 0 deg C, 2) 4h, RT 2: 93 percent / N2 / palladium black / 1 h / Ambient temperature 3: 1) 6.1n HCl, isoamyl nitrite, 2) triethylamine / 1) -30deg C, THF, 30 min; 2) -45deg C, DMF, 15h between -5deg C to 0deg C View Scheme