3,5-二氯-4-硝基苯酚合成路线 （共 9 条）
反应条件
sodium dithionite; sodium carbonate
参考文献
Hodgson; Wignall
Journal of the Chemical Society, 1927 , p. 2218
Journal of the Chemical Society, 1928 , p. 331
反应条件
1: potassium carbonate; xylene 2: tin; concentrated hydrochloric acid View Scheme
参考文献
Joshi; Vyas; Duffel; Parkin; Lehmler
Synthesis, 2011 , # 7 p. 1045 - 1054
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 1 h;
参考文献
Joshi; Vyas; Duffel; Parkin; Lehmler
Synthesis, 2011 , # 7 p. 1045 - 1054
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; Methylation; 1 h;
参考文献
Waterhouse, Ian
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 11 p. 1075 - 1083
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 90 °C 2: hydrogenchloride; 10 palladium on activated charcoal; hydrogen / methanol 3: palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene / 16 h / 20 °C / Reflux; Inert atmosphere View Scheme
参考文献
Li, Jianqing; Smith, Daniel; Krishnananthan, Subramaniam; Hartz, Richard A.; Dasgupta, Bireshwar; Ahuja, Vijay; Schmitz, William D.; Bronson, Joanne J.; Mathur, Arvind; Barrish, Joel C.; Chen, Bang-Chi
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 156 - 159
反应条件
1: 3,5-dichloro-4-nitrophenol With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.333333 h; Inert atmosphere; 2: chloro-difluoro-acetic acid methyl ester in N,N-dimethyl-formamide T=90°C; 2 h; Inert atmosphere; 3: With water in ethyl acetate; N,N-dimethyl-formamide
参考文献
Li, Jianqing; Smith, Daniel; Krishnananthan, Subramaniam; Hartz, Richard A.; Dasgupta, Bireshwar; Ahuja, Vijay; Schmitz, William D.; Bronson, Joanne J.; Mathur, Arvind; Barrish, Joel C.; Chen, Bang-Chi
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 156 - 159
反应条件
sulfuric acid; sodium nitrite in water
6 h; Reflux;
参考文献
Li, Jianqing; Smith, Daniel; Krishnananthan, Subramaniam; Hartz, Richard A.; Dasgupta, Bireshwar; Ahuja, Vijay; Schmitz, William D.; Bronson, Joanne J.; Mathur, Arvind; Barrish, Joel C.; Chen, Bang-Chi
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 156 - 159
参考文献
Willstaetter; Schudel
Chemische Berichte, 1918 , vol. 51, p. 785
Full Text Show Details
Hodgson; Wignall
Journal of the Chemical Society, 1927 , p. 2218
Journal of the Chemical Society, 1928 , p. 331
参考文献
Hodgson; Wignall
Journal of the Chemical Society, 1927 , p. 2218
Journal of the Chemical Society, 1928 , p. 331
