5-溴-2-(甲巯基)-4-嘧啶甲酸合成路线 （共 16 条）
反应条件
in methoxybenzene 0.333333 h; microwave irradiation;
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 2 p. 219 - 224
反应条件
Erhitzen ueber den Schmelzpunkt;
参考文献
McOmie; White
Journal of the Chemical Society, 1953 , p. 3129
反应条件
potassium hydroxide; hydrogen; Pd-BaSO4 in methanol P=1810.02 Torr;
参考文献
Kim, Chong-Ho; Marquez, Victor E.; Mao, David T.; Haines, David R.; McCormack, John J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1374 - 1380
反应条件
potassium hydroxide; conc HCl; nitrogen in methanol
参考文献
Liverton, Nigel J.; Butcher, John W.; McIntyre, Charles; Claiborne, Christopher F.; Claremon, David A.; McCauley, John A.; Romano, Joseph J.; Thompson, Wayne; Munson, Peter M.
Patent: US2003/119811 A1, 2003 ;
US 20030119811 A1
反应条件
hydrogenchloride
T=60 - 70°C; 1 h;
参考文献
Budesinsky; Vavrina; Langsadl; Holubek
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 2 p. 539 - 547
反应条件
1: 98 percent / KOH, H2 / 5percent Pd/BaSO4 / methanol / 1810.02 Torr
2: 68 percent / N,N-dimethylchloromethyleniminium chloride, NaBH4 / CH2Cl2; tetrahydrofuran; acetonitrile; dimethylformamide / 3 h / -78 - -20 °C
3: 71 percent / methanol / 12 h / Heating
View Scheme
参考文献
Kim, Chong-Ho; Marquez, Victor E.; Mao, David T.; Haines, David R.; McCormack, John J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1374 - 1380
