4-(3,4-二氯苯基)-4-氧代丁酸合成路线 （共 14 条）
反应条件
aluminium trichloride T=60°C; 2.5 h;
参考文献
Quallich, George J.; Williams, Michael T.; Friedmann, Robert C.
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4971 - 4973
参考文献
American Cyanamid Company
Patent: US4226775 A1, 1980 ;
US 4226775 A
反应条件
1: N2H4, KOH / ethane-1,2-diol 2: polyphosphoric acid View Scheme
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; CHOREV, Michael; AKTAS, Bertal Huseyin; HALPERIN, Jose A.; WAGNER, Gerhard
Patent: WO2012/6068 A2, 2012 ;
反应条件
hydrogenchloride; mercury dichloride; zinc in water; toluene 36 h; Reflux;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; CHOREV, Michael; AKTAS, Bertal Huseyin; HALPERIN, Jose A.; WAGNER, Gerhard
Patent: WO2012/6068 A2, 2012 ;
Location in patent: Page/Page column 87-89 ;
反应条件
1: N2H4, KOH / ethane-1,2-diol 2: polyphosphoric acid View Scheme
参考文献
Baker; Hopkins
Journal of medicinal chemistry, 1970 , vol. 13, # 1 p. 87 - 89
反应条件
1: aq. NaOH (pH 10.73), NaBH4 / 2 h / 78 °C 2: aq. HCl / 1) 65 - 70 deg C, 4 h, 2) rt, 16 h 3: 97 percent / anh. hydrogen fluoride / 18 h / Ambient temperature View Scheme
参考文献
Quallich, George J.; Williams, Michael T.; Friedmann, Robert C.
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4971 - 4973
反应条件
1: NaBH4, 1N aq. NaOH / 18 h / Ambient temperature 2: 10.33 g / LiAlH4 / tetrahydrofuran / 1) 1 h, ice-bath, 2) 1 h, 25 deg C, 3) 1.5 h, 60 deg C 3: 98 percent / imidazole / dimethylformamide / 18 h / ice-bath temp. to r.t. 4: 97 percent / Et3N / CH2Cl2 / 0.25 h / 0 °C 5: 1) CuCN / 1) Et2O, a) -20 deg C, 20 min, b) 0 deg C, 30 min, 2) Et2O, a) -25 deg C, 18 h, b) r.t., 5.5 h 6: 91 percent / AcOH, water / tetrahydrofuran / 24 h / Ambient temperature 7: 95 percent / Jones reagent / acetone / 2 h / Ambient temperature 8: CF3SO3H / benzene / 2 h / 70 °C View Scheme
参考文献
Quallich; Woodall
Tetrahedron, 1992 , vol. 48, # 47 p. 10239 - 10248
反应条件
1: NaBH4, 1N aq. NaOH / 18 h / Ambient temperature
2: 10.33 g / LiAlH4 / tetrahydrofuran / 1) 1 h, ice-bath, 2) 1 h, 25 deg C, 3) 1.5 h, 60 deg C
3: 98 percent / imidazole / dimethylformamide / 18 h / ice-bath temp. to r.t.
4: 97 percent / Et3N / CH2Cl2 / 0.25 h / 0 °C
5: 1) CuCN / 1) Et2O, a) -20 deg C, 20 min, b) 0 deg C, 30 min, 2) Et2O, a) -25 deg C, 18 h, b) r.t., 5.5 h
6: 91 percent / AcOH, water / tetrahydrofuran / 24 h / Ambient temperature
7: 95 percent / Jones reagent / acetone / 2 h / Ambient temperature
8: CF3SO3H / benzene / 2 h / 70 °C
View Scheme
参考文献
Quallich; Woodall
Tetrahedron, 1992 , vol. 48, # 47 p. 10239 - 10248
反应条件
1: 1) NaBH4, 1N aq. NaOH, 2) conc. HCl / 1) 18 h, r.t., 2) water, CH2Cl2, a) 1 h, r.t., 2) 1.75 h, 45 deg C
2: AlCl3
View Scheme
参考文献
Quallich, George J.; Williams, Michael T.; Friedmann, Robert C.
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4971 - 4973
反应条件
1: NaBH4, 1N aq. NaOH / 18 h / Ambient temperature
2: 10.33 g / LiAlH4 / tetrahydrofuran / 1) 1 h, ice-bath, 2) 1 h, 25 deg C, 3) 1.5 h, 60 deg C
3: 98 percent / imidazole / dimethylformamide / 18 h / ice-bath temp. to r.t.
4: 97 percent / Et3N / CH2Cl2 / 0.25 h / 0 °C
5: 1) CuCN / 1) Et2O, a) -20 deg C, 20 min, b) 0 deg C, 30 min, 2) Et2O, a) -25 deg C, 18 h, b) r.t., 5.5 h
6: 91 percent / AcOH, water / tetrahydrofuran / 24 h / Ambient temperature
7: 95 percent / Jones reagent / acetone / 2 h / Ambient temperature
8: CF3SO3H / benzene / 2 h / 70 °C
View Scheme
参考文献
Quallich; Woodall
Tetrahedron, 1992 , vol. 48, # 47 p. 10239 - 10248
