4-(3,4-二氯苯基)-4-氧代丁酸合成路线 （共 14 条）
反应条件
1: 58 percent / 24 h / Heating
2: 86 percent / H2NNH2, AcOH / H2O / 2 h / Heating
View Scheme
参考文献
Goeschke, R; Gainer, J; Howarth, GA; Wallis, RB; Kerry, R; et al.
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 7 p. 715 - 721
参考文献
Goeschke, R; Gainer, J; Howarth, GA; Wallis, RB; Kerry, R; et al.
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 7 p. 715 - 721
反应条件
1: hydrogenchloride; mercury dichloride; zinc / toluene; water / 36 h / Reflux
2: polyphosphoric acid / 10 h / 130 °C
3: bromine / diethyl ether / 0.5 h / 20 °C
View Scheme
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; CHOREV, Michael; AKTAS, Bertal Huseyin; HALPERIN, Jose A.; WAGNER, Gerhard
Patent: WO2012/6068 A2, 2012 ;
反应条件
1: aq. NaOH (pH 10.73), NaBH4 / 2 h / 78 °C
2: aq. HCl / 1) 65 - 70 deg C, 4 h, 2) rt, 16 h
View Scheme
参考文献
Quallich, George J.; Williams, Michael T.; Friedmann, Robert C.
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4971 - 4973
