3-乙基-4-羟基-6-甲基-2H-吡喃-2-酮合成路线 （共 6 条）
反应条件
sodium cyanoborohydride in acetic acid
1 h;
参考文献
Nutaitis, Charles F.; Schultz, Rose Ann; Obaza, Judy; Smith, Francis X.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4606 - 4608
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in benzene
Heating;
参考文献
Cervello, Jordi; Marquet, Jorge; Moreno-Manas, Marcial
Tetrahedron Letters, 1987 , vol. 28, # 32 p. 3715 - 3716
反应条件
1: trifluoroacetic acid / 5 h / Heating
2: Et3SiH, LiClO4 / trifluoroacetic acid / 4 h / Ambient temperature
View Scheme
参考文献
Lokot, Igor P.; Pashkovsky, Felix S.; Lakhvich, Fedor A.
Tetrahedron, 1999 , vol. 55, # 15 p. 4783 - 4792
反应条件
1: 76 percent / toluene / Heating
2: trifluoroacetic acid / 5 h / Heating
3: Et3SiH, LiClO4 / trifluoroacetic acid / 4 h / Ambient temperature
View Scheme
参考文献
Lokot, Igor P.; Pashkovsky, Felix S.; Lakhvich, Fedor A.
Tetrahedron, 1999 , vol. 55, # 15 p. 4783 - 4792
反应条件
1: 1.) copper acetate, water, methanol, 2.) sodium hydride, THF, reflux, 5 min.
2: 88 percent / DBU / benzene / 1.5 h / Heating
View Scheme
参考文献
Cervello, Jordi; Marquet, Jorge; Moreno-Manas, Marcial
Tetrahedron Letters, 1987 , vol. 28, # 32 p. 3715 - 3716
反应条件
methanol; dimethylsulfide borane complex
1.) THF, RT, 1 h, 2.) THF, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Shimizu, Takeshi; Hiranuma, Sayoko; Watanabe, Tsumoru
Heterocycles, 1993 , vol. 36, # 11 p. 2445 - 2450
