1: 1.) sulfuryl chloride 2.) sodium bicarbonate / 1.) methylene chloride, 20 deg C, 1 h 2.) water, 5 min 2: 72 percent / sodium bicarbonate, potassium iodide, iodine / H2O / 1 h / 75 °C 3: 80 percent / zinc powder / acetic acid / 3 h / 140 °C 4: hydrogen, 10percent Pd on charcoal / methanol / 1 h / 2585.7 Torr 5: 1.7 g / dicyclohexylcarbodiimide / tetrahydrofuran / 17 h / 20 °C 6: 62 percent / p-toluenesulfonic acid / CH2Cl2 / 5 h / 41 °C 7: 57 percent / hydrogen, 10percent Pd on charcoal / ethanol / 2 h / 2585.7 Torr 8: 1.) sodium bicarbonate, iodine 2.) hydrogen, 10percent Pd/C, sodium acetate / 1.) ethanol, 30 min, 20 deg C 2.) ethanol, 50 psi, 2 h 9: 60 percent / dimethylformamide / 1 h / 20 °C 10: 1.) HBr 2.) hydrogen, 10percent Pd on charcoal, (morpholinomethyl)polystyrene / 1.) methanol, 15 min, 20 deg C; glacial acetic acid, 90 min, 20 deg C 2.) chloroform, methanol, 1 h, 40 psi 11: saponification 12: 20 percent / 37 °C / pH=7.4 View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: 60 percent<br />2: 1.) CCl₄, Mg / 1.) ethanol, reflux, 6 h; 2.) reflux, 3 h, 5 deg C<br />3: 16 percent<br /> <br /> &nbsp;