1: 2.) sodium hydroxide / 1.) DMSO, 20 deg C, 30 min, 2.) DMSO, water 2: 1.) sodium ethanethiolate, 2.) sodium hydroxide / 1.) DMSO, 70 deg C, 30 min, 2.) DMSO, water View Scheme

1: isothioquinanthrene; sodium thiomethoxide in dimethyl sulfoxide T=20°C; Ring cleavage; 1 h; 2: methyl iodide Methylation; 0.5 h;

1: isothioquinanthrene; sodium thiomethoxide in dimethyl sulfoxide T=20°C; Ring cleavage; 1 h; 2: methyl iodide Methylation; 0.5 h;

multi step reaction; various nucleophiles and alkyl halides; Mechanism;