反应条件
1: pivalaldehyde; cyanoacetic acid ethyl ester With pyrrolidine in ethanol
T=20°C; 5 h;
2: 2,2-Dimethyl-[1,3]dioxane-4,6-dione With sodium hydroxide in ethanol; water
T=20 - 70°C;
3: With sodium hydroxide in ethylene glycol
T=150°C; 24 h; Further stages.;
参考文献
Yang, Jerry; Gabriele, Bartolo; Belvedere, Sandro; Huang, Ying; Breslow, Ronald
The Journal of organic chemistry, 2002 , vol. 67, # 15 p. 5057 - 5067
