tert.-butylnitrite in acetonitrile T=60°C; 1 h;

1: 5-bromo-2-iodobenzonitrile With iso-propylmagnesium bromide in tetrahydrofuran T=-40°C; 0.833333 h; 2: in tetrahydrofuran T=-40°C; 0.25 h; 3: 3-bromo-2-(bromomethyl)-1-propene in tetrahydrofuran T=-40°C; 3 h; Further stages.;

1.1: 86 percent / tert-butyl nitrite; I2 / acetonitrile / 1 h / 23 °C 2.1: i-PrMgBr / tetrahydrofuran / 0.83 h / -40 °C 2.2: CuCN*2LiCl / tetrahydrofuran / 0.25 h / -40 °C 2.3: 35 percent Spectr. / tetrahydrofuran / 3 h / -40 °C View Scheme