2-羟基-4-(三氟甲基)吡啶合成路线 （共 10 条）
反应条件
chloro-trimethyl-silane; zinc in tetrahydrofuran T=40°C; Inert atmosphereReflux;
参考文献
Xiong, Wen-Nan; Yang, Cai-Guang; Jiang, Biao
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 7 p. 1773 - 1780
反应条件
sulfuric acid; sodium nitrite in water T=70°C; 1 h;
参考文献
Dunn
Journal of Fluorine Chemistry, 1999 , vol. 93, # 2 p. 153 - 157
反应条件
1: chloro-trimethyl-silane With zinc in tetrahydrofuran 0.5 h; Inert atmosphere; 2: ETFBO; chloroacetonitrile in tetrahydrofuran T=20 - 40°C; 2 h; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; water 1 h; RefluxInert atmosphere;
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
1: With sodium methylate in methanol T=0 - 20°C; 2.75 h; 2: With ammonium acetate in formamide T=130 - 160°C; 3.46667 h; Product distribution / selectivity;
参考文献
Dow AgroSciences LLS
Patent: US2009/5569 A1, 2009 ;
Location in patent: Page/Page column 7 ;
反应条件
1: trifluoroacetic acid chloride; ethyl vinyl ether T=0 - 20°C; 0.5 h; 2: methanol T=0°C; 3: dimethyl methoxycarbonylmethanephosphonate With ammonium acetate; sodium methylate Product distribution / selectivity; more than 3 stages;
参考文献
Dow AgroSciences LLS
Patent: US2009/5569 A1, 2009 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: 76 percent / NH3 / H2O / 24 h / 170 °C 2: 72 percent / H2SO4, NaNO2 / H2O / 1 h / 70 °C View Scheme
参考文献
Dunn
Journal of Fluorine Chemistry, 1999 , vol. 93, # 2 p. 153 - 157
反应条件
phosphorus pentachloride; trichlorophosphate 3 h; Heating;
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
bromine in acetic acid
参考文献
Gleave, Robert J.; Beswick, Paul J.; Brown, Andrew J.; Giblin, Gerard M.P.; Haslam, Carl P.; Livermore, David; Moses, Andrew; Nicholson, Neville H.; Page, Lee W.; Slingsby, Brian; Swarbrick, Martin E.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6578 - 6581
反应条件
Lawesson's reagent in toluene
参考文献
Dunn
Journal of Fluorine Chemistry, 1999 , vol. 93, # 2 p. 153 - 157
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20 - 80°C; 13 h;
参考文献
Sagasser, Ingo; Menke, Olaf; Hamprecht, Gerhard; Puhl, Michael; Reinhard, Robert; Witschel, Matthias; Zagar, Cyrill; Walter, Helmut
Patent: US2003/216257 A1, 2003 ;
Location in patent: Page/Page column 36-37 ;
