4-氰基-4'-甲基联苯合成路线 （共 60 条）
反应条件
potassium carbonate; polymer-supported Pd catalyst FC 1001 in ethylene glycol dimethyl ether; ethanol T=100°C; Suzuki coupling; 0.166667 h; microwave irradiation;
参考文献
Liu, Chun; Rao, Xiaofeng; Zhang, Yixia; Li, Xinmin; Qiu, Jieshan; Jin, Zilin
European Journal of Organic Chemistry, 2013 , # 20 p. 4345 - 4350
反应条件
NHC-Pd(II)-Im; tetrabutyl ammonium fluoride in toluene T=120°C; Hiyama reaction; 3 h; Inert atmosphere;
参考文献
Gu, Zheng-Song; Shao, Li-Xiong; Lu, Jian-Mei
Journal of Organometallic Chemistry, 2012 , vol. 700, p. 132 - 134
反应条件
tetrabutyl ammonium fluoride; potassium carbonate in water T=100°C; Suzuki-Miyaura coupling; 22 h;
参考文献
Yamada, Yoichi M. A.; Sarkar, Shaheen M.; Uozumi, Yasuhiro
Journal of the American Chemical Society, 2012 , vol. 134, # 6 p. 3190 - 3198
反应条件
((C6H4)(OPPh2)(NCHPhPPh2))NiCl in tetrahydrofuran T=25°C; Kumada cross-coupling; 12 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Zhong-Xia
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10031 - 10038
反应条件
1: para-bromotoluene With lithium 2: With zinc(II) chloride 3: para-chloro-benzonitrile With nickel amido phosphine pincer complex in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=70°C; Negishi cross-coupling; 12 h; Further stages.;
参考文献
Wang, Li; Wang, Zhong-Xia
Organic Letters, 2007 , vol. 9, # 21 p. 4335 - 4338
反应条件
triethylamine; palladium diacetate in ethanol T=80°C; Suzuki-Miyaura cross-coupling;
参考文献
Zhang, Liang; Meng, Tianhao; Wu, Jie
Journal of Organic Chemistry, 2007 , vol. 72, # 24 p. 9346 - 9349
反应条件
2,2'-bis(di-p-tolyl-phosphino)-1,1'-binaphthyl; copper(I) oxide; 1,10-phenanthroline; palladium (II) bromide in 1-methyl-pyrrolidin-2-one T=50 - 190°C; Microwave irradiationInert atmosphere;
参考文献
Goossen, Lukas J.; Linder, Christophe; Rodriguez, Nuria; Lange, Paul P.
Chemistry - A European Journal, 2009 , vol. 15, # 37 p. 9336 - 9349
反应条件
sodium; palladium diacetate in nitrogen
参考文献
Mitsubishi Kasei Corporation
Patent: US5159082 A1, 1992 ;
反应条件
Ni(Cl){2-(Ph2P(O))C6H4NCH(Ph)PPh2} in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=25°C; Negishi coupling reaction; 24 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Li; Wang, Zhong-Xia
Chemical Communications, 2011 , vol. 47, # 5 p. 1598 - 1600
反应条件
potassium phosphate; N-[(4-diphenylphosphinophenyl)methyl] D-gluconamide; PdCl2(GLCAphos)2 in water T=80°C; 16 h;
参考文献
Nishimura, Masato; Ueda, Masato; Miyaura, Norio
Tetrahedron, 2002 , vol. 58, # 29 p. 5779 - 5787
