4-氰基-4'-甲基联苯合成路线 （共 60 条）
反应条件
potassium fluoride; bis(benzonitrile)palladium(II) dichloride in tetrahydrofuran T=25°C; Suzuki-Miyaura Coupling; 16 h; Inert atmosphereSealed tube;
参考文献
Iwai, Tomohiro; Tanaka, Ryotaro; Harada, Tomoya; Sawamura, Masaya
Chemistry - A European Journal, 2014 , vol. 20, # 4 p. 1057 - 1065
反应条件
potassium fluoride; bis(η3-allyl-μ-chloropalladium(II)) in N,N-dimethyl-formamide T=100°C; 21 h;
参考文献
Hatanaka, Yasuo; Fukushima, Satoshi; Hiyama, Tamejiro
Chemistry Letters, 1989 , p. 1711 - 1714
Title/Abstract Full Text Show Details
Hatanaka, Yasuo; Goda, Ken-ichi; Okahara, Yoshinori; Hiyama, Tamejiro
Tetrahedron, 1994 , vol. 50, # 28 p. 8301 - 8316
反应条件
1,3-phenylene-bis-(1H)-tetrazole; caesium carbonate; palladium diacetate in N,N-dimethyl-formamide T=80°C; Suzuki cross-coupling reaction; 8 h;
参考文献
Gupta, Arun Kumar; Rim, Chul Yun; Oh, Chang Ho
Synlett, 2004 , # 12 p. 2227 - 2229
反应条件
caesium carbonate; triphenylphosphine; palladium dichloride in N,N-dimethyl acetamide T=90°C; 2 h;
参考文献
Rao, Maddali L.N.; Jadhav, Deepak N.; Banerjee, Debasis
Tetrahedron, 2008 , vol. 64, # 24 p. 5762 - 5772
反应条件
caesium carbonate; triphenylphosphine; palladium dichloride in N,N-dimethyl acetamide T=90°C; 1 h;
参考文献
Rao, Maddali L.N.; Jadhav, Deepak N.; Banerjee, Debasis
Tetrahedron, 2008 , vol. 64, # 24 p. 5762 - 5772
反应条件
potassium fluoride; palladium diacetate; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide T=120°C; 20 h;
参考文献
Hatanaka, Yasuo; Goda, Ken-ichi; Okahara, Yoshinori; Hiyama, Tamejiro
Tetrahedron, 1994 , vol. 50, # 28 p. 8301 - 8316
反应条件
tetrabutylammomium bromide; caesium carbonate; triphenylphosphine; palladium dichloride in N,N-dimethyl acetamide T=90°C; 1 h;
参考文献
Rao, Maddali L.N.; Jadhav, Deepak N.; Banerjee, Debasis
Tetrahedron, 2008 , vol. 64, # 24 p. 5762 - 5772
反应条件
1: 1-(iodo)-4-methylbenzene With chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc in tetrahydrofuran T=150°C; 0.5 h; Inert atmosphereMicrowave irradiation; 2: para-chloro-benzonitrile With n-butyllithium; nickel-in-charcoal; triphenylphosphine in tetrahydrofuran; 1,4-dioxane; hexane T=150°C; Negishi cross-coupling reaction; P=3750.38 Torr; 0.25 h; Inert atmosphereMicrowave irradiation;
参考文献
Irfan, Muhammed; Fuchs, Michael; Glasnov, Toma N.; Kappe, C. Oliver
Chemistry - A European Journal, 2009 , vol. 15, # 43 p. 11608 - 11618
反应条件
NiCl2[(4-MeOPh)3P]2; K3PO4*3H2O; tris(4-methoxyphenyl)-phosphine in toluene T=110°C; 5 h; Inert atmosphere;
参考文献
Chen, Xiaofeng; Ke, Haihua; Zou, Gang
ACS Catalysis, 2014 , vol. 4, # 2 p. 379 - 385
反应条件
ethylene glycol dimethyl ether; Pd(1,3-bis(diphenylphosphino)-propane)Cl2 in tetrahydrofuran T=20°C; 0.6 h;
参考文献
Riguet, Eric; Alami, Mouad; Cahiez, Gerard
Journal of Organometallic Chemistry, 2001 , vol. 624, # 1-2 p. 376 - 379
