4-氰基-4'-甲基联苯合成路线 （共 60 条）
参考文献
Catalytica Pharmaceuticals, Inc.
Patent: US5922898 A1, 1999 ;
反应条件
triphenylphosphine in tetrahydrofuran; water; toluene
参考文献
Great Lakes Chemical Konstanz GmbH
Patent: US6121480 A1, 2000 ;
反应条件
1,3-bis-(diphenylphosphino)propane; potassium carbonate; nickel dichloride in 1,4-dioxane T=100°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Zhao, Yu-Long; Li, You; Li, Yu; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2010 , vol. 16, # 17 p. 4991 - 4994
反应条件
C68H72Cl2N6NiP2; lithium chloride; zinc(II) chloride in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=25°C; Kumada coupling reaction; 4 h; Inert atmosphere;
参考文献
Xie, Lan-Gui; Wang, Zhong-Xia
Chemistry - A European Journal, 2010 , vol. 16, # 34 p. 10332 - 10336
反应条件
toluene-4-sulfonic acid; orthoformic acid triethyl ester; copper(l) chloride; sodium nitrite T=50°C; Gomberg-Bachmann-Hey reaction; 0.75 h;
参考文献
Chaturbhuj, Ganesh U.; Akamanchi, Krishnacharya G.
Tetrahedron Letters, 2011 , vol. 52, # 38 p. 4950 - 4953
反应条件
5-palladium/activated carbon; potassium carbonate in ethanol; water T=50°C; Suzuki-Miyaura coupling; 24 h;
参考文献
LeBlond, Carl R.; Butler, Kaycie M.; Ferrington, Marc W.; Browe, Matthew A.
Synthetic Communications, 2009 , vol. 39, # 4 p. 636 - 640
反应条件
potassium phosphate; Ni(PCy3)2Cl2; tri-cyclo-hexyl-phosphine in 1,4-dioxane; water T=110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Yu, Da-Gang; Yu, Miao; Guan, Bing-Tao; Li, Bi-Jie; Zheng, Yang; Wu, Zhen-Hua; Shi, Zhang-Jie
Organic Letters, 2009 , vol. 11, # 15 p. 3374 - 3377
反应条件
(Ph3P)2Pd(Ph)(I) in N,N-dimethyl-formamide 2 h; Heating;
参考文献
Bumagin, N. A.; Luzikova, E. V.; Beletskaya, I. P.
Russian Journal of Organic Chemistry, 1995 , vol. 31, # 11 p. 1480 - 1486
Zhurnal Organicheskoi Khimii, 1995 , vol. 31, # 11 p. 1650 - 1656
反应条件
palladium 10 on activated carbon in methanol Suzuki-Miyaura cross-coupling; RefluxUnder air;
参考文献
Hanna Jr., James M.; Varnedoe, Lee S.; Angel, Brad D.; McClellan, Joshua L.
Letters in Organic Chemistry, 2010 , vol. 7, # 1 p. 1 - 6
反应条件
bis-triphenylphosphine-palladium(II) chloride; lithium chloride in N,N-dimethyl-formamide Inert atmosphere;
参考文献
Sanchez, Ana I.; Martinez-Barrasa, Valentin; Burgos, Carolina; Vaquero, Juan J.; Alvarez-Builla, Julio; Terricabras, Emma; Segarra, Victor
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2370 - 2378
