4-(4-溴甲基苯基)苯甲腈合成路线 （共 4 条）
反应条件
phosphorus tribromide in dichloromethane T=0 - 20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION; BOUILLOT, Anne Marie Jeanne; DODIC, Nerina; GELLIBERT, Francoise Jeanne; MIRGUET, Olivier
Patent: WO2010/15652 A2, 2010 ;
Location in patent: Page/Page column 47 ;
WO 2010/015652 A2
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane Bromination; 2.5 h; Heating;
参考文献
Wachall, Bertil G.; Hector, Markus; Zhuang, Yan; Hartmann, Rolf W.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1913 - 1924
反应条件
1: 83 percent / t-BuLi; ZnCl2 / Pd(PPh3)4 / tetrahydrofuran; pentane / 2.5 h / Heating 2: 52 percent / NBS; dibenzoyl peroxide / CCl4 / 2.5 h / Heating View Scheme
参考文献
Shaw, Kenneth J.; Guilford, William J.; Griedel, Brian D.; Sakata, Steve; Trinh, Lan; Wu, Shung; Xu, Wei; Zhao, Zuchun; Morrissey, Michael M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 9 p. 1311 - 1314
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 80 °C / Inert atmosphere 2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 40 h / 80 °C / Inert atmosphere View Scheme
参考文献
Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Brodrecht, Martin; Pilakowski, Johannes; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris
European Journal of Medicinal Chemistry, 2013 , vol. 61, p. 26 - 40
