4'-甲酰基-4-联苯甲腈合成路线 （共 11 条）
反应条件
methanol; sodium tetrahydroborate T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION; BOUILLOT, Anne Marie Jeanne; DODIC, Nerina; GELLIBERT, Francoise Jeanne; MIRGUET, Olivier
Patent: WO2010/15653 A1, 2010 ;
Location in patent: Page/Page column 38 ;
WO 2010/015653 A1
反应条件
C28H40Br4N4Pd2; potassium carbonate in water; acetone
T=20°C; Suzuki Coupling; 1 h;
参考文献
Gupta, Sumanta; Basu, Basudeb; Das, Sajal
Tetrahedron, 2013 , vol. 69, # 1 p. 122 - 128
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=90°C; 3 h;
参考文献
SMITHKLINE BEECHAM CORPORATION; BOUILLOT, Anne Marie Jeanne; DODIC, Nerina; GELLIBERT, Francoise Jeanne; MIRGUET, Olivier
Patent: WO2010/15652 A2, 2010 ;
Location in patent: Page/Page column 45-46 ;
WO 2010/015652 A2
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; triphenylphosphine in water; N,N-dimethyl-formamide
T=100°C; Suzuki-Miyaura cross-coupling; Inert atmosphere;
参考文献
Bonin, Helne; Leuma-Yona, Rodrigue; Marchiori, Bruno; Demonchaux, Patrice; Gras, Emmanuel
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1132 - 1135
反应条件
KF in tetrahydrofuran
参考文献
Yale University
Patent: US6562989 B2, 2003 ;
反应条件
1: 4-bromobenzaldehyde diethyl acetal With magnesium in tetrahydrofuran
1 h;
2: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran
T=20°C; 0.5 h;
3: para-bromobenzonitrile in tetrahydrofuran
16 h; Further stages.;
参考文献
Ballav, Nirmalya; Schuepbach, Bjoern; Dethloff, Ole; Feulner, Peter; Terfort, Andreas; Zharnikov, Michael
Journal of the American Chemical Society, 2007 , vol. 129, # 50 p. 15416 - 15417
反应条件
ammonia in N-methyl-acetamide; water
参考文献
Hoffmann La Roche Inc.
Patent: US5238602 A1, 1993 ;
反应条件
4,4'-(phenylphosphinediyl)bis(2,6-dimethylmorpholine); caesium carbonate; tris(dibenzylideneacetone)dipalladium (0) in 1,4-dioxane
Suzuki-Miyaura coupling; 6 h; Heating;
参考文献
Cho, Su-Dong; Kim, Ho-Kyun; Yim, Heung-seop; Kim, Mi-Ra; Lee, Jin-Kook; Kim, Jeum-Jong; Yoon, Yong-Jin
Tetrahedron, 2007 , vol. 63, # 6 p. 1345 - 1352
反应条件
potassium carbonate in ethanol; water
T=50°C; Suzuki coupling; 20 h;
参考文献
Gruttadauria, Michelangelo; Bivona, Lucia Anna; Lo Meo, Paolo; Riela, Serena; Noto, Renato
European Journal of Organic Chemistry, 2012 , # 13 p. 2635 - 2642
反应条件
1: para-iodobenzonitrile With copper; zinc in N,N-dimethyl-formamide
T=100°C; 0.166667 h;
2: 4-bromo-benzaldehyde With bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=120°C; Negishi cross-coupling reaction; 0.0833333 h; Further stages.;
参考文献
Mutule, Ilga; Suna, Edgars
Tetrahedron Letters, 2004 , vol. 45, # 20 p. 3909 - 3912
