2,2-二甲基四氢-2H-吡喃-4-基)甲醇合成路线 （共 3 条）
反应条件
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide in dichloromethane T=20°C; 2 h; Molecular sieveInert atmosphere;
参考文献
NOVARTIS AG; ANTONIOS-MCCREA, William, R.; BARSANTI, Paul, A.; HU, Cheng; JIN, Xianming; MARTIN, Eric, J.; PAN, Yue; PFISTER, Keith, B.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng
Patent: WO2012/66070 A1, 2012 ;
Location in patent: Page/Page column 108 ;
WO 2012/066070 A1
反应条件
1: With sodium tetrahydroborate in ethanol
T=0 - 50°C; 3 h;
2: With ethanol
Acidic conditions;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/101867 A1, 2008 ;
Location in patent: Page/Page column 91 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; pyridine / dichloromethane / 18 h / 20 °C
2: ammonia / tetrahydrofuran / 18 h / -78 - 125 °C
View Scheme
参考文献
NOVARTIS AG; ANTONIOS-MCCREA, William R.; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; MARTIN, Eric J.; PAN, Yue; PFISTER, Keith B.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng
Patent: WO2012/66065 A1, 2012 ;
WO 2012/066065 A1
